KC01
IC50 value of KC01 is 90 +/- 20 nM for ABHD16A
General
Type : Oxooxetan
Chemical_Nomenclature : (6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide
Canonical SMILES : CCCCCCCCCCCCCC1C(=CCCCCC(=O)N)C(=O)O1
InChI : InChI=1S\/C22H39NO3\/c1-2-3-4-5-6-7-8-9-10-11-14-17-20-19(22(25)26-20)16-13-12-15-18-21(23)24\/h16,20H,2-15,17-18H2,1H3,(H2,23,24)\/b19-16-
InChIKey : RJBBAPPWVJEOMC-MNDPQUGUSA-N
Other name(s) : (Z)-6-(2-Oxo-4-tridecyloxetan-3-ylidene)hexanamide,CHEMBL4525638,SCHEMBL17760784,SCHEMBL17760785,BDBM195603
MW : 365.5
Formula : C22H39NO3
CAS_number : 1646795-59-6
PubChem : 86289046
UniChem : RJBBAPPWVJEOMC-MNDPQUGUSA-N
IUPHAR :
Wikipedia :
Target
Families : KC01 ligand of proteins in family: Cholesterol_esterase || ABHD16
Stucture :
References (2)
| Title : Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS-Activated Microglia - Minamihata_2021_Neurochem.Res__ |
| Author(s) : Minamihata T , Takano K , Nakamura Y , Seto R , Moriyama M |
| Ref : Neurochem Res , : , 2021 |
| Abstract : Minamihata_2021_Neurochem.Res__ |
| ESTHER : Minamihata_2021_Neurochem.Res__ |
| PubMedSearch : Minamihata_2021_Neurochem.Res__ |
| PubMedID: 34383250 |
| Gene_locus related to this paper: human-ABHD12B |
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : Kamat_2015_Nat.Chem.Biol_11_164 |
| ESTHER : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |