JW480 is a selective inhibitor of human-NCEH1 (KIAA1363, AADACL1) (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes) It inhibits moderately also CES1 and CES2
Type : Carbamate,Naphthalen
Chemical_Nomenclature : (2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate
Canonical SMILES : CC(C)C1=CC=CC=C1OC(=O)NCCC2=CC3=CC=CC=C3C=C2
InChI :
InChIKey : PCNJGBMWAZRVEA-UHFFFAOYSA-N
Other name(s) : SCHEMBL4433152,JW 480,JW-480,ZINC71746265,AKOS024458096
MW : 333.42
Formula : C22H23NO2
CAS_number : 1354359-53-7
PubChem : 57330099
UniChem : PCNJGBMWAZRVEA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : JW480 ligand of proteins in family: Arylacetamide_deacetylase
Stucture :
Protein : human-NCEH1
Title : A potent and selective inhibitor of KIAA1363\/AADACL1 that impairs prostate cancer pathogenesis - Chang_2011_Chem.Biol_18_476 |
Author(s) : Chang JW , Nomura DK , Cravatt BF |
Ref : Chemical Biology , 18 :476 , 2011 |
Abstract : Chang_2011_Chem.Biol_18_476 |
ESTHER : Chang_2011_Chem.Biol_18_476 |
PubMedSearch : Chang_2011_Chem.Biol_18_476 |
PubMedID: 21513884 |
Gene_locus related to this paper: human-NCEH1 |