JMN4
JMN4 exhibited superior potency for inhibiting recombinant mouse (IC50 = 90 nM) and human (IC50 = 5.9 nM) Lp-PLA2 compared to either WWL153 (IC50 = 290 nM for mouse Lp-PLA2; IC50 = 250 nM for human Lp-PLA2) or P9 (IC50 = 470 nM for mouse Lp-PLA2; IC50 = 100 nM for human Lp-PLA2)
General
Type : Piperazine,Quinoline
Chemical_Nomenclature : (4-phenylphenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate
Canonical SMILES : CC1=NC2=CC=CC=C2C(=C1)N3CCN(CC3)C(=O)OC4=CC=C(C=C4)C5=CC=CC=C5
InChI : InChI=1S\/C27H25N3O2\/c1-20-19-26(24-9-5-6-10-25(24)28-20)29-15-17-30(18-16-29)27(31)32-23-13-11-22(12-14-23)21-7-3-2-4-8-21\/h2-14,19H,15-18H2,1H3
InChIKey : VJMDOENKGACNEX-UHFFFAOYSA-N
Other name(s) : MLS003874821,CHEMBL2132835,SMR002531605,SR-02000001696,SR-02000001696-1
MW : 423.5
Formula : C27H25N3O2
CAS_number :
PubChem : 53364494
UniChem : VJMDOENKGACNEX-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) - Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| Author(s) : Nagano JM , Hsu KL , Whitby LR , Niphakis MJ , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder P , Srinivasan P , Gonzalez TD , Rosen H , Bahnson BJ , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :839 , 2013 |
| Abstract : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| ESTHER : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedSearch : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedID: 23260346 |