JJH221
Broad spectrum inhibitor of serine hydrolases ABHD6, MGLL, ABHD4, ABHD12, PLA2G15, PNPLA4
General
Type : Carbamate,Piperidine,N-hydroxyhydantoin,tert-Butyloxycarbonyl,tert-Butyl
Chemical_Nomenclature : tert-butyl 2-[4-[2-(4-chlorophenyl)ethyl]piperidine-1-carbonyl]oxy-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazine-7-carboxylate
Canonical SMILES : CC(C)(C)OC(=O)N1CCN2C(C1)C(=O)N(C2=O)OC(=O)N3CCC(CC3)CCC4=CC=C(C=C4)Cl
InChI : InChI=1S\/C25H33ClN4O6\/c1-25(2,3)35-23(33)28-14-15-29-20(16-28)21(31)30(22(29)32)36-24(34)27-12-10-18(11-13-27)5-4-17-6-8-19(26)9-7-17\/h6-9,18,20H,4-5,10-16H2,1-3H3
InChIKey : AZRWYMZCYCWVSN-UHFFFAOYSA-N
Other name(s) : SCHEMBL17275305,SR-02000002572,SR-02000002572-1
MW : 521.0
Formula : C25H33ClN4O6
CAS_number :
PubChem : 71710925
UniChem : AZRWYMZCYCWVSN-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (1)
| Title : Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases - Cognetta_2015_Chem.Biol_22_928 |
| Author(s) : Cognetta AB, 3rd , Niphakis MJ , Lee HC , Martini ML , Hulce JJ , Cravatt BF |
| Ref : Chemical Biology , 22 :928 , 2015 |
| Abstract : Cognetta_2015_Chem.Biol_22_928 |
| ESTHER : Cognetta_2015_Chem.Biol_22_928 |
| PubMedSearch : Cognetta_2015_Chem.Biol_22_928 |
| PubMedID: 26120000 |