Indol-thioxotetrahydropyrimidine-Cpd7
IC50 AChE 2.54 and BChE 0.207 microM
General
Type : Sulfur Compound,Indole,Pyrimidine
Chemical_Nomenclature : 1-Amino-4-(4-bromophenyl)-6-(1H-indol-3-yl)-2-thioxohydropyrimidine-5(2H)-one
Canonical SMILES : N1(C(C(C(N(C1=S)N([H])[H])C2=C[N]C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Br)[H]
InChI : InChI=1S\/C18H15BrN4OS\/c19-11-7-5-10(6-8-11)15-17(24)16(23(20)18(25)22-15)13-9-21-14-4-2-1-3-12(13)14\/h1-9,15-16,21H,20H2,(H,22,25)
InChIKey : YUTXDQUOMMCHQD-UHFFFAOYSA-N
Other name(s) : Compound 7
MW : 415.30
Formula : C18H15BrN4OS
CAS_number :
PubChem :
UniChem : YUTXDQUOMMCHQD-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Indol-thioxotetrahydropyrimidine-Cpd7 ligand of proteins in family: BCHE
Stucture :
Protein : human-BCHE
References (1)
| Title : New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics - Azmy_2023_Future.Med.Chem_15_473 |
| Author(s) : Azmy EM , Nassar IF , Hagras M , Fawzy IM , Hegazy M , Mokhtar MM , Yehia AM , Ismail NS , Lashin WH |
| Ref : Future Med Chem , 15 :473 , 2023 |
| Abstract : Azmy_2023_Future.Med.Chem_15_473 |
| ESTHER : Azmy_2023_Future.Med.Chem_15_473 |
| PubMedSearch : Azmy_2023_Future.Med.Chem_15_473 |
| PubMedID: 37125532 |