Heparin-disaccharide
Heparin is a naturally occurring anticoagulant produced by basophils and mast cells. Heparin is a polymer of varying chain size. In therapeutic doses, it acts as an anticoagulant, preventing the formation of clots
General
Type : Sulfur Compound,Glycoside
Chemical_Nomenclature : (2R,3R,4S)-2-[(2R,3S,4R,5R,6S)-4,6-dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4-hydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid
Canonical SMILES : C1=C(OC(C(C1O)OS(=O)(=O)O)OC2C(OC(C(C2O)NS(=O)(=O)O)O)COS(=O)(=O)O)C(=O)O
InChI : InChI=1S\/C12H19NO19S3\/c14-3-1-4(10(16)17)30-12(8(3)32-35(25,26)27)31-9-5(2-28-34(22,23)24)29-11(18)6(7(9)15)13-33(19,20)21\/h1,3,5-9,11-15,18H,2H2,(H,16,17)(H,19,20,21)(H,22,23,24)(H,25,26,27)\/t3-,5+,6+,7+,8+,9+,11-,12-\/m0\/s1
InChIKey : LRPGJWKAYQRIAQ-GYBHJADLSA-N
Other name(s) : Heparin disaccharide I-S,H1S,AC1L9MEK,HP_dp02_0009,CHEBI:138683,Alpha-delta4,5-UA(2S)-(1-4)-alpha-D-GlcpNS(6S)
MW : 577.45
Formula : C12H19NO19S3
CAS_number :
PubChem : 448837
UniChem : LRPGJWKAYQRIAQ-GYBHJADLSA-N
IUPHAR :
Wikipedia : Heparin
Target
Families : Heparin-disaccharide ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 4UYW Structure of the human wnt deacetylase notum - Crystal form I heparin complex - 1.7A
Protein : human-NOTUM
References (1)
| Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187 |
| Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP |
| Ref : Nature , 519 :187 , 2015 |
| Abstract : Kakugawa_2015_Nature_519_187 |
| ESTHER : Kakugawa_2015_Nature_519_187 |
| PubMedSearch : Kakugawa_2015_Nature_519_187 |
| PubMedID: 25731175 |
| Gene_locus related to this paper: drome-q9vux3 , human-NOTUM |