HALSTS1
N-(3,5-dichloro-2-ethoxybenzyl)-2H-tetrazol-5-amine as a nanomolar HALoTag2 Stabilizer (HALTS1) that reduces the Hsp70:HaloTag2 interaction, thereby preventing HaloTag2 ubiquitination and degradation
General
Type : HaloTag-ligand,Tetrazol
Chemical_Nomenclature : N-[(3,5-dichloro-2-ethoxyphenyl)methyl]-2H-tetrazol-5-amine
Canonical SMILES : CCOC1=C(C=C(C=C1CNC2=NNN=N2)Cl)Cl
InChI : InChI=1S\/C10H11Cl2N5O\/c1-2-18-9-6(3-7(11)4-8(9)12)5-13-10-14-16-17-15-10\/h3-4H,2,5H2,1H3,(H2,13,14,15,16,17)
InChIKey : KCYVZGKDTVPASH-UHFFFAOYSA-N
Other name(s) : STK510523,AN-465\/42519283,ASN 13154749,AC1NGJT0,MolPort-000-124-829,MolPort-008-310-670
MW : 288.13
Formula : C10H11Cl2N5O
CAS_number :
PubChem : 4725455
UniChem : KCYVZGKDTVPASH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : HALSTS1 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture : 4KYV Crystal Structure of dehalogenase HaloTag2 with HALTS at the resolution 1.8A. Northeast Structural Genomics Consortium (NESG) Target OR150
Protein : rhoso-halo1
References (1)
| Title : A bidirectional system for the dynamic small molecule control of intracellular fusion proteins - Neklesa_2013_ACS.Chem.Biol_8_2293 |
| Author(s) : Neklesa TK , Noblin DJ , Kuzin AP , Lew S , Seetharaman J , Acton TB , Kornhaber GJ , Xiao R , Montelione GT , Tong L , Crews CM |
| Ref : ACS Chemical Biology , 8 :2293 , 2013 |
| Abstract : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| ESTHER : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| PubMedSearch : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| PubMedID: 23978068 |
| Gene_locus related to this paper: rhoso-halo1 |