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Inhibitor Report for: Gramine

Indole alkaloid from the plant Arundo donax, Gramineae. Inhibitor of acetylcholinesterase and butyrylcholinesterase. a competitive serotonin antagonist


General
Type Alkaloid, Natural, Not A/B H target, Indole
Chemical_Nomenclature 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
Canonical SMILES CN(C)CC1=CNC2=CC=CC=C21
InChI InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3
InChIKey OCDGBSUVYYVKQZ-UHFFFAOYSA-N
Other name(s) Donaxine ; Donaxin ; Gramin ; Indolalkylamine der. ; beta-Dimethylaminomethylindole ; b-(Dimethylaminomethyl)indole ; 3-[(Dimethylamino)methyl]indole ; Indol-3-ylmethyldimethylamine ; 3-(Dimethylaminomethyl)indole
________________________________________________________________________________________________
MW|174
Formula|C11H14N2
CAS_number|87-52-5
PubChem|6890
UniChem|OCDGBSUVYYVKQZ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Gramine

Target
Families | Gramine ligand of proteins in family: ACHE, BCHE

References:
Search PubMed for references concerning: Gramine
    Title: Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors
    Lockhart B, Closier M, Howard K, Steward C, Lestage P
    Ref: Naunyn Schmiedebergs Arch Pharmacol, 363:429, 2001 : PubMed