Fragment-823
Not inhibitor of Notum. Compound 46 Fragment 823 IC50 380+/-130 microM
General
Type : Fragment inhibitor of Notum,Pyrimidine
Chemical_Nomenclature : 4-methoxy-6-phenylpyrimidin-2-amine
Canonical SMILES : COC1=NC(=NC(=C1)C2=CC=CC=C2)N
InChI : InChI=1S\/C11H11N3O\/c1-15-10-7-9(13-11(12)14-10)8-5-3-2-4-6-8\/h2-7H,1H3,(H2,12,13,14)
InChIKey : NVXGRADJIFIBIO-UHFFFAOYSA-N
Other name(s) : Fragment 823,TE5,Compound 46,4-methoxy-6-phenylpyrimidin-2-amine,4-methoxy-6-phenyl-pyrimidin-2-amine,CBMicro_018540,ChemDiv2_003370,Cambridge id 5343571
MW : 201.22
Formula : C11H11N3O
CAS_number :
PubChem : 676910
UniChem : NVXGRADJIFIBIO-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture : 7BD3 Structure of the human Wnt deacylase Notum in complex with fragment 823
Protein :
References (1)
| Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
| Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
| Abstract : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| ESTHER : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedID: 35731924 |
| Gene_locus related to this paper: human-NOTUM |