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Inhibitor Report for: Fragment-147

Not inhibitor of Notum. Compound 10 Fragment 147 IC50 700+/-100 micr


General
Type Fragment inhibitor of Notum, Carboxamide, Pyridine, Not A/B H target
Chemical_Nomenclature 2-methyl-N-(2-methylpropyl)imidazo[1,2-a]pyridine-3-carboxamide
Canonical SMILES CC1=C(N2C=CC=CC2=N1)C(=O)NCC(C)C
InChI InChI=1S/C13H17N3O/c1-9(2)8-14-13(17)12-10(3)15-11-6-4-5-7-16(11)12/h4-7,9H,8H2,1-3H3,(H,14,17)
InChIKey QQNPIZGIGPGFPW-UHFFFAOYSA-N
Other name(s) Fragment 147 ; GRV ; N-isobutyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide ; Oprea1_380040 ; MLS000698354 ; CHEMBL1381910 ; HMS2593O16 ; HMS3382C22
________________________________________________________________________________________________
MW|231.29
Formula|C13H17N3O
CAS_number|
PubChem|757612
UniChem|QQNPIZGIGPGFPW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Fragment-147 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7B8C: Structure of the human Wnt deacylase Notum in complex with fragment 147
Protein | human-NOTUM

References:
Search PubMed for references concerning: Fragment-147
    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed