ERX-41
IT IS NOT AN INHIBITOR BUT A SPECIFIC LIGAND. Liu et al. published that targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. They disclosed ERX-41 which specifically interacts with LIPA (human-LIPA)
General
Type : Oligobenzamide
Chemical_Nomenclature : 4-[[4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-3-(2-methylpropoxy)benzoyl]amino]-N-(4-methylcyclohexyl)-3-(2-methylpropoxy)benzamide
Canonical SMILES : CC1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC(=O)C3=CC(=C(C=C3)NC(=O)C4=CC(=C(C=C4)[N+](=O)[O-])OCCO)OCC(C)C)OCC(C)C
InChI : InChI=1S\/C38H48N4O9\/c1-23(2)21-50-33-18-26(36(44)39-29-11-6-25(5)7-12-29)8-13-30(33)40-37(45)27-9-14-31(34(19-27)51-22-24(3)4)41-38(46)28-10-15-32(42(47)48)35(20-28)49-17-16-43\/h8-10,13-15,18-20,23-25,29,43H,6-7,11-12,16-17,21-22H2,1-5H3,(H,39,44)(H,40,45)(H,41,46)
InChIKey : QOYORXKDWMJNHD-UHFFFAOYSA-N
Other name(s) :
MW : 704.8
Formula : C38H48N4O9
CAS_number :
PubChem : 153603617
UniChem : QOYORXKDWMJNHD-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress - Liu_2022_Nat.Cancer__ |
| Author(s) : Liu X , Viswanadhapalli S , Kumar S , Lee TK , Moore A , Ma S , Chen L , Hsieh M , Li M , Sareddy GR , Parra K , Blatt EB , Reese TC , Zhao Y , Chang A , Yan H , Xu Z , Pratap UP , Liu Z , Roggero CM , Tan Z , Weintraub ST , Peng Y , Tekmal RR , Arteaga CL , Lippincott-Schwartz J , Vadlamudi RK , Ahn JM , Raj GV |
| Ref : Nat Cancer , : , 2022 |
| Abstract : Liu_2022_Nat.Cancer__ |
| ESTHER : Liu_2022_Nat.Cancer__ |
| PubMedSearch : Liu_2022_Nat.Cancer__ |
| PubMedID: 35654861 |
| Gene_locus related to this paper: human-LIPA |