EHDPP
hCE1b, human hepatic carboxylesterase IC50 99.4 +/- 65.6 nM
General
Type : Organophosphorus flame retardant plasticizer,Organophosphate
Chemical_Nomenclature : 2-ethylhexyl diphenyl phosphate
Canonical SMILES : CCCCC(CC)COP(=O)(OC1=CC=CC=C1)OC2=CC=CC=C2
InChI : InChI=1S\/C20H27O4P\/c1-3-5-12-18(4-2)17-22-25(21,23-19-13-8-6-9-14-19)24-20-15-10-7-11-16-20\/h6-11,13-16,18H,3-5,12,17H2,1-2H3
InChIKey : CGSLYBDCEGBZCG-UHFFFAOYSA-N
Other name(s) : 2-Ethylhexyl diphenyl phosphate,Octicizer,Phosphoric acid, 2-ethylhexyl diphenyl ester,Santicizer 141,SCHEMBL93483,CHEMBL2105213,CHEBI:188855,EHDPHP
MW : 362.4
Formula : C20H27O4P
CAS_number : 1241-94-7
PubChem : 14716
UniChem : CGSLYBDCEGBZCG-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (9)
| Title : Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes - Tsugoshi_2020_Chem.Biol.Interact__109148 |
| Author(s) : Tsugoshi Y , Watanabe Y , Tanikawa Y , Inoue C , Sugihara K , Kojima H , Kitamura S |
| Ref : Chemico-Biological Interactions , :109148 , 2020 |
| Abstract : Tsugoshi_2020_Chem.Biol.Interact__109148 |
| ESTHER : Tsugoshi_2020_Chem.Biol.Interact__109148 |
| PubMedSearch : Tsugoshi_2020_Chem.Biol.Interact__109148 |
| PubMedID: 32511959 |
| Title : Adipogenic activity of 2-ethylhexyl diphenyl phosphate via peroxisome proliferator-activated receptor gamma pathway - Sun_2020_Sci.Total.Environ_711_134810 |
| Author(s) : Sun W , Duan X , Chen H , Zhang L , Sun H |
| Ref : Sci Total Environ , 711 :134810 , 2020 |
| Abstract : Sun_2020_Sci.Total.Environ_711_134810 |
| ESTHER : Sun_2020_Sci.Total.Environ_711_134810 |
| PubMedSearch : Sun_2020_Sci.Total.Environ_711_134810 |
| PubMedID: 31812418 |
| Title : Perinatal exposure to 2-Ethylhexyl Diphenyl Phosphate (EHDPHP) affected the metabolic homeostasis of male mouse offspring: Unexpected findings help to explain dose- and diet- specific phenomena - Yan_2020_J.Hazard.Mater_388_122034 |
| Author(s) : Yan S , Wang D , Teng M , Meng Z , Yan J , Li R , Jia M , Tian S , Zhou Z , Zhu W |
| Ref : J Hazard Mater , 388 :122034 , 2020 |
| Abstract : Yan_2020_J.Hazard.Mater_388_122034 |
| ESTHER : Yan_2020_J.Hazard.Mater_388_122034 |
| PubMedSearch : Yan_2020_J.Hazard.Mater_388_122034 |
| PubMedID: 31951990 |
| Title : Inhibition of Human Liver Carboxylesterase (hCE1) by Organophosphate Ester Flame Retardants and Plasticizers: Implications for Pharmacotherapy - Phillips_2019_Toxicol.Sci_171_396 |
| Author(s) : Phillips AL , Stapleton HM |
| Ref : Toxicol Sci , 171 :396 , 2019 |
| Abstract : Phillips_2019_Toxicol.Sci_171_396 |
| ESTHER : Phillips_2019_Toxicol.Sci_171_396 |
| PubMedSearch : Phillips_2019_Toxicol.Sci_171_396 |
| PubMedID: 31268531 |
| Title : Aryl-phosphorus-containing flame retardants induce oxidative stress, the p53-dependent DNA damage response and mitochondrial impairment in A549 cells - Yuan_2019_Environ.Pollut_250_58 |
| Author(s) : Yuan S , Han Y , Ma M , Rao K , Wang Z , Yang R , Liu Y , Zhou X |
| Ref : Environ Pollut , 250 :58 , 2019 |
| Abstract : Yuan_2019_Environ.Pollut_250_58 |
| ESTHER : Yuan_2019_Environ.Pollut_250_58 |
| PubMedSearch : Yuan_2019_Environ.Pollut_250_58 |
| PubMedID: 30981936 |
| Title : Urinary biomarkers for assessment of human exposure to monomeric aryl phosphate flame retardants - Zhao_2019_Environ.Int_124_259 |
| Author(s) : Zhao F , Kang Q , Zhang X , Liu J , Hu J |
| Ref : Environ Int , 124 :259 , 2019 |
| Abstract : Zhao_2019_Environ.Int_124_259 |
| ESTHER : Zhao_2019_Environ.Int_124_259 |
| PubMedSearch : Zhao_2019_Environ.Int_124_259 |
| PubMedID: 30660026 |
| Title : Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate - Hu_2017_Environ.Sci.Technol_51_4061 |
| Author(s) : Hu W , Gao F , Zhang H , Hiromori Y , Arakawa S , Nagase H , Nakanishi T , Hu J |
| Ref : Environ Sci Technol , 51 :4061 , 2017 |
| Abstract : Hu_2017_Environ.Sci.Technol_51_4061 |
| ESTHER : Hu_2017_Environ.Sci.Technol_51_4061 |
| PubMedSearch : Hu_2017_Environ.Sci.Technol_51_4061 |
| PubMedID: 28282128 |
| Title : In vitro metabolism of 2-ethylhexyldiphenyl phosphate (EHDPHP) by human liver microsomes - Ballesteros-Gomez_2015_Toxicol.Lett_232_203 |
| Author(s) : Ballesteros-Gomez A , Erratico CA , Eede NV , Ionas AC , Leonards PE , Covaci A |
| Ref : Toxicol Lett , 232 :203 , 2015 |
| Abstract : Ballesteros-Gomez_2015_Toxicol.Lett_232_203 |
| ESTHER : Ballesteros-Gomez_2015_Toxicol.Lett_232_203 |
| PubMedSearch : Ballesteros-Gomez_2015_Toxicol.Lett_232_203 |
| PubMedID: 25448284 |
| Title : Isolation and identification of metabolites of 2-ethylhexyl diphenyl phosphate in rats - Nishimaki-Mogami_1988_Arch.Toxicol_61_259 |
| Author(s) : Nishimaki-Mogami T , Minegishi K , Tanaka A , Sato M |
| Ref : Archives of Toxicology , 61 :259 , 1988 |
| Abstract : Nishimaki-Mogami_1988_Arch.Toxicol_61_259 |
| ESTHER : Nishimaki-Mogami_1988_Arch.Toxicol_61_259 |
| PubMedSearch : Nishimaki-Mogami_1988_Arch.Toxicol_61_259 |
| PubMedID: 3377680 |