E1N
General
Type : Derivative of Tacrine,Derivative of Huperzine
Chemical_Nomenclature : 12-Amino-3-chloro-6,7,10,11-tetrahydro-5,9-dimethyl-7,11-methanocycloocta[b]quinolin-5-ium
Canonical SMILES : CCC1=C[C@H]2C[C@@H](C1)c1c(N)c3ccc(Cl)cc3[n+](C)c1C2
InChI : InChI=1S\/C19H21ClN2\/c1-3-11-6-12-8-13(7-11)18-17(9-12)22(2)16-10-14(20)4-5-15(16)19(18)21\/h4-6,10,12-13,21H,3,7-9H2,1-2H3\/p+1\/t12-,13+\/m0\/s1
InChIKey : UDYIKCNLONGUCX-QWHCGFSZSA-O
Other name(s) :
MW : 313.84
Formula : C19H22ClN2
CAS_number :
PubChem : 132472271
UniChem : UDYIKCNLONGUCX-QWHCGFSZSA-O
IUPHAR :
Wikipedia :
Target
Families : E1N ligand of proteins in family: ACHE
Stucture : 6G1V Crystal structure of Torpedo Californica acetylcholinesterase in complex with 12-Amino-3-chloro-6,7,10,11-tetrahydro-5,9-dimethyl-7,11-methanocycloocta[b]quinolin-5-ium
Protein : torca-ACHE
References (1)
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |