E1K
General
Type : Derivative of Tacrine
Chemical_Nomenclature : 6-chloranyl-10-methyl-1,2,3,4-tetrahydroacridin-10-ium-9-amine
Canonical SMILES : C[n+]1c2CCCCc2c(N)c2ccc(Cl)cc12
InChI : InChI=1S\/C14H15ClN2\/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)17\/h6-8,16H,2-5H2,1H3\/p+1
InChIKey : NNLSQYGKFPZYHI-UHFFFAOYSA-O
Other name(s) :
MW : 247.74
Formula : C14H16ClN2
CAS_number :
PubChem : 132472270
UniChem : NNLSQYGKFPZYHI-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Target
Families : E1K ligand of proteins in family: ACHE
Stucture : 6G1U Crystal structure of Torpedo Californica acetylcholinesterase in complex with 9-Amino-6-chloro-1,2,3,4-tetrahydro-10-methylacridin-10-ium
Protein : torca-ACHE
References (1)
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |