multi-target-directed ligand combination therapy of donepezil and the quinone drug idebenone with antioxidant and antiaggregating properties
Type : Multitarget,Antioxidant,anti-Abeta-aggregation,Derivative of Donepezil
Chemical_Nomenclature :
Canonical SMILES : C1=CC2=C(C=C1)C(C(=C(C2=O)C)NC3CCN(CC3)CC4=CC=CC=C4)=O
InChI : InChI=1S\/C23H24N2O2\/c1-16-21(23(27)20-10-6-5-9-19(20)22(16)26)24-18-11-13-25(14-12-18)15-17-7-3-2-4-8-17\/h2-10,18,24H,11-15H2,1H3
InChIKey : DDAKLCVNBJVDEK-UHFFFAOYSA-N
Other name(s) :
MW : 360.45
Formula : C23H24N2O2
CAS_number :
PubChem :
UniChem : DDAKLCVNBJVDEK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Donepezil-idebenone-cpd9 ligand of proteins in family: BCHE
Stucture :
Protein : human-BCHE
Title : Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy - Perone_2021_ChemMedChem_16_187 |
Author(s) : Perone R , Albertini C , Uliassi E , Di Pietri F , de Sena Murteira Pinheiro P , Petralla S , Rizzardi N , Fato R , Pulkrabkova L , Soukup O , Tramarin A , Bartolini M , Bolognesi ML |
Ref : ChemMedChem , 16 :187 , 2021 |
Abstract : Perone_2021_ChemMedChem_16_187 |
ESTHER : Perone_2021_ChemMedChem_16_187 |
PubMedSearch : Perone_2021_ChemMedChem_16_187 |
PubMedID: 32716144 |