Diazepan-AJH
General
Type : Trifluoro,Diazepan,Azepane
Chemical_Nomenclature : 4-[4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carbonyl]benzoic acid
Canonical SMILES : C1CN(CCN(C1)C(=O)C2=CC=C(C=C2)C(=O)O)C(=O)CC(CC3=CC(=C(C=C3F)F)F)N
InChI : InChI=1S\/C23H24F3N3O4\/c24-18-13-20(26)19(25)11-16(18)10-17(27)12-21(30)28-6-1-7-29(9-8-28)22(31)14-2-4-15(5-3-14)23(32)33\/h2-5,11,13,17H,1,6-10,12,27H2,(H,32,33)\/t17-\/m1\/s1
InChIKey : NXUBRAZWHJADLI-QGZVFWFLSA-N
Other name(s) : AJH,CHEMBL482154,CHEMBL1186902,BDBM50256569,(R)-4-(4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepane-1-carbonyl)benzoic acid hydrochloride,4-({4-[(3r)-3-Amino-4-(2,4,5-Trifluorophenyl)butanoyl]-1,4-Diazepan-1-Yl}carbonyl)benzoic Acid
MW : 463.45
Formula : C23H24F3N3O4
CAS_number :
PubChem : 25021195
UniChem : NXUBRAZWHJADLI-QGZVFWFLSA-N
IUPHAR :
Wikipedia :
Target
Families : Diazepan-AJH ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 3EIO Crystal Structure Analysis of DPPIV Inhibitor
Protein : human-DPP4
References (2)
| Title : Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors - Ahn_2008_Bioorg.Med.Chem.Lett_18_6525 |
| Author(s) : Ahn JH , Park WS , Jun MA , Shin MS , Kang SK , Kim KY , Rhee SD , Bae MA , Kim KR , Kim SG , Kim SY , Sohn SK , Kang NS , Lee JO , Lee DH , Cheon HG , Kim SS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :6525 , 2008 |
| Abstract : Ahn_2008_Bioorg.Med.Chem.Lett_18_6525 |
| ESTHER : Ahn_2008_Bioorg.Med.Chem.Lett_18_6525 |
| PubMedSearch : Ahn_2008_Bioorg.Med.Chem.Lett_18_6525 |
| PubMedID: 18996694 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors - Jun_2008_Eur.J.Med.Chem_43_1889 |
| Author(s) : Jun MA , Park WS , Kang SK , Kim KY , Kim KR , Rhee SD , Bae MA , Kang NS , Sohn SK , Kim SG , Lee JO , Lee DH , Cheon HG , Kim SS , Ahn JH |
| Ref : Eur Journal of Medicinal Chemistry , 43 :1889 , 2008 |
| Abstract : Jun_2008_Eur.J.Med.Chem_43_1889 |
| ESTHER : Jun_2008_Eur.J.Med.Chem_43_1889 |
| PubMedSearch : Jun_2008_Eur.J.Med.Chem_43_1889 |
| PubMedID: 18243422 |
| Gene_locus related to this paper: human-DPP4 |