AChE IC50 15.1 +/- 0.2 nM
Type : Multitarget,Acridine,Derivative of Tacrine,Antioxidant,tert-Butyl,Alkyl linked bis-ligand
Chemical_Nomenclature : 2,6-Di-tert-butyl-4-{[8-(1,2,3,4-tetrahydro-acridin-9-ylamino)-octylamino]-methyl}-phenol
Canonical SMILES : C1=CC=C2C(=C1)N=C4C(=C2NCCCCCCCCNCC3=CC(=C(C(=C3)C(C)(C)C)O)C(C)(C)C)CCCC4
InChI : InChI=1S\/C36H53N3O\/c1-35(2,3)29-23-26(24-30(34(29)40)36(4,5)6)25-37-21-15-9-7-8-10-16-22-38-33-27-17-11-13-19-31(27)39-32-20-14-12-18-28(32)33\/h11,13,17,19,23-24,37,40H,7-10,12,14-16,18,20-22,25H2,1-6H3,(H,38,39)
InChIKey : UIRADPAVLKLALA-UHFFFAOYSA-N
Other name(s) : 17d
MW : 543.83
Formula : C36H53N3O
CAS_number :
PubChem :
UniChem : UIRADPAVLKLALA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Di-tert-butyl-phenol-octylamino-acridine-17d ligand of proteins in family: ACHE
Stucture :
Protein : human-ACHE
Title : Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease - Makhaeva_2024_Molecules_29_321 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serkov IV , Proshin AN , Soldatova YV , Poletaeva DA , Faingold, II , Mumyatova VA , Terentiev AA , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
Ref : Molecules , 29 :321 , 2024 |
Abstract : Makhaeva_2024_Molecules_29_321 |
ESTHER : Makhaeva_2024_Molecules_29_321 |
PubMedSearch : Makhaeva_2024_Molecules_29_321 |
PubMedID: 38257233 |