DTT-adduct
dithiothreitol and CO2 present during the protein purification formed a tetrahedral 1,4-dithio-2,3-butylene carbonate adduct with Ser117 in the active site
General
Type : Dioxolane,Sulfur Compound
Chemical_Nomenclature : (4S,5S)-4,5-bis(sulfanylmethyl)-1,3-dioxolane-2,2-diol
Canonical SMILES : C(C1C(OC(O1)(O)O)CS)S
InChI : InChI=1S\/C5H10O4S2\/c6-5(7)8-3(1-10)4(2-11)9-5\/h3-4,6-7,10-11H,1-2H2\/t3-,4-\/m1\/s1
InChIKey : GTKQHVOANQENIG-QWWZWVQMSA-N
Other name(s) : (4s,5s)-4,5-Bis(Mercaptomethyl)-1,3-Dioxolan-2-Ol,DBC
MW : 198.25
Formula : C5H10O4S2
CAS_number :
PubChem : 44631828
UniChem : GTKQHVOANQENIG-QWWZWVQMSA-N
IUPHAR :
Wikipedia :
Target
Families : DTT-adduct ligand of proteins in family: Cocaine_esterase
Stucture :
Protein : rhosm-cocE
References (2)
| Title : Structural analysis of thermostabilizing mutations of cocaine esterase - Narasimhan_2010_Protein.Eng.Des.Sel_23_537 |
| Author(s) : Narasimhan D , Nance MR , Gao D , Ko MC , MacDonald J , Tamburi P , Yoon D , Landry DM , Woods JH , Zhan CG , Tesmer JJ , Sunahara RK |
| Ref : Protein Engineering Des Sel , 23 :537 , 2010 |
| Abstract : Narasimhan_2010_Protein.Eng.Des.Sel_23_537 |
| ESTHER : Narasimhan_2010_Protein.Eng.Des.Sel_23_537 |
| PubMedSearch : Narasimhan_2010_Protein.Eng.Des.Sel_23_537 |
| PubMedID: 20436035 |
| Gene_locus related to this paper: rhosm-cocE |
| Title : A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse - Brim_2010_Mol.Pharmacol_77_593 |
| Author(s) : Brim RL , Nance MR , Youngstrom DW , Narasimhan D , Zhan CG , Tesmer JJ , Sunahara RK , Woods JH |
| Ref : Molecular Pharmacology , 77 :593 , 2010 |
| Abstract : Brim_2010_Mol.Pharmacol_77_593 |
| ESTHER : Brim_2010_Mol.Pharmacol_77_593 |
| PubMedSearch : Brim_2010_Mol.Pharmacol_77_593 |
| PubMedID: 20086035 |
| Gene_locus related to this paper: rhosm-cocE |