DOTA-(amide)4-(EG)n-tetraphosphonate
These linkers are based on a tetra-aza scaffold having four acetic acid arms (ubiquitous chelator DOTA 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), each of which is linked to a para-nitro-phenylphosphonate (referred to as the DOTA-(amide)4-(EG)n-tetraphosphonate or DOTP). The phosphonate group is an irreversible inhibitor of the fungal esterase cutinase and reacts with an active-site serine residue (Ser 120) to give a phosphonate linkage. Linkers can bind 4 molecules of cutinase with different length of tether (L) m=3, n=5 (M) m=1,n=5, (S) m=1, n=1 giving rise to a megamolecule
General
Type : Polymer,Poly-ethylene-glycol,Organophosphate,pNP
Chemical_Nomenclature :
Canonical SMILES :
InChI :
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Other name(s) :
MW : 2410.46 || 2058.04 || 1833.61
Formula : C104H172N16O40P4 || C88H140N16O32P4 || C72H108N16O32P4
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Wikipedia :
4-(EG)n-tetraphosphonate.gif)
Target
Families : DOTA-(amide)4-(EG)n-tetraphosphonate ligand of proteins in family: Cutinase
Stucture :
Protein : fusso-cutas
References (1)
| Title : Synthesis, Characterization, and Simulation of Four-Armed Megamolecules - Zhou_2021_Biomacromolecules__ |
| Author(s) : Zhou S , He P , Dhindwal S , Grum-Tokars VL , Li Y , Parker K , Modica JA , Bleher R , Dos Reis R , Zuchniarz J , Dravid VP , Voth GA , Roux B , Mrksich M |
| Ref : Biomacromolecules , : , 2021 |
| Abstract : Zhou_2021_Biomacromolecules__ |
| ESTHER : Zhou_2021_Biomacromolecules__ |
| PubMedSearch : Zhou_2021_Biomacromolecules__ |
| PubMedID: 33979120 |
| Gene_locus related to this paper: fusso-cutas |