DO264
General
Type : Urea derivative,Sulfur Compound
Chemical_Nomenclature : 1-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]pyridin-2-yl]piperidin-4-yl]-3-pyridin-3-ylthiourea
Canonical SMILES : C1CN(CCC1NC(=S)NC2=CN=CC=C2)C3=NC=CC(=C3Cl)OC4=C(C=C(C=C4)OC(F)(F)F)Cl
InChI : InChI=1S\/C23H20Cl2F3N5O2S\/c24-17-12-16(35-23(26,27)28)3-4-18(17)34-19-5-9-30-21(20(19)25)33-10-6-14(7-11-33)31-22(36)32-15-2-1-8-29-13-15\/h1-5,8-9,12-14H,6-7,10-11H2,(H2,31,32,36)
InChIKey : PIEQDBPBBQPLPL-UHFFFAOYSA-N
Other name(s) : DO-264,DO-26,DO 264,HY-114157,CS-0077182
MW : 558.40
Formula : C23H20Cl2F3N5O2S
CAS_number :
PubChem : 134813646
UniChem : PIEQDBPBBQPLPL-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (4)
| Title : Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS-Activated Microglia - Minamihata_2021_Neurochem.Res__ |
| Author(s) : Minamihata T , Takano K , Nakamura Y , Seto R , Moriyama M |
| Ref : Neurochem Res , : , 2021 |
| Abstract : Minamihata_2021_Neurochem.Res__ |
| ESTHER : Minamihata_2021_Neurochem.Res__ |
| PubMedSearch : Minamihata_2021_Neurochem.Res__ |
| PubMedID: 34383250 |
| Gene_locus related to this paper: human-ABHD12B |
| Title : Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells - Kathman_2020_ACS.Chem.Biol_15_871 |
| Author(s) : Kathman SG , Boshart J , Jing H , Cravatt BF |
| Ref : ACS Chemical Biology , 15 :871 , 2020 |
| Abstract : Kathman_2020_ACS.Chem.Biol_15_871 |
| ESTHER : Kathman_2020_ACS.Chem.Biol_15_871 |
| PubMedSearch : Kathman_2020_ACS.Chem.Biol_15_871 |
| PubMedID: 32195565 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase alpha\/beta-Hydrolase Domain-Containing 12 (ABHD12) - Ogasawara_2019_J.Med.Chem_62_1643 |
| Author(s) : Ogasawara D , Ichu TA , Jing H , Hulce JJ , Reed A , Ulanovskaya OA , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 62 :1643 , 2019 |
| Abstract : Ogasawara_2019_J.Med.Chem_62_1643 |
| ESTHER : Ogasawara_2019_J.Med.Chem_62_1643 |
| PubMedSearch : Ogasawara_2019_J.Med.Chem_62_1643 |
| PubMedID: 30720278 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo - Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| Author(s) : Ogasawara D , Ichu TA , Vartabedian VF , Benthuysen J , Jing H , Reed A , Ulanovskaya OA , Hulce JJ , Roberts A , Brown S , Rosen H , Teijaro JR , Cravatt BF |
| Ref : Nat Chemical Biology , 14 :1099 , 2018 |
| Abstract : Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| ESTHER : Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| PubMedSearch : Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| PubMedID: 30420694 |
| Gene_locus related to this paper: human-ABHD12 |