Cyclic-Hydrazine-Derivative
General
Type : Trifluoro,Diazepan,Azepane
Chemical_Nomenclature : (3R)-3-amino-1-(2-benzoyldiazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Canonical SMILES : C1CCN(N(CC1)C(=O)C2=CC=CC=C2)C(=O)CC(CC3=CC(=C(C=C3F)F)F)N
InChI : InChI=1S\/C22H24F3N3O2\/c23-18-14-20(25)19(24)12-16(18)11-17(26)13-21(29)27-9-5-2-6-10-28(27)22(30)15-7-3-1-4-8-15\/h1,3-4,7-8,12,14,17H,2,5-6,9-11,13,26H2\/t17-\/m1\/s1
InChIKey : XXRHRPGYYNOBHO-QGZVFWFLSA-N
Other name(s) : KR2,CHEMBL513425,(2r)-4-(2-Benzoyl-1,2-Diazepan-1-Yl)-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-Amine,CHEMBL539611,BDBM50206820,BDBM50256266,DB08051
MW : 419.44
Formula : C22H24F3N3O2
CAS_number :
PubChem : 16739331
UniChem : XXRHRPGYYNOBHO-QGZVFWFLSA-N
IUPHAR :
Wikipedia :
Target
Families : Cyclic-Hydrazine-Derivative ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 2OLE Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives
Protein : human-DPP4
References (1)
| Title : Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors - Ahn_2007_Bioorg.Med.Chem.Lett_17_2622 |
| Author(s) : Ahn JH , Shin MS , Jun MA , Jung SH , Kang SK , Kim KR , Rhee SD , Kang NS , Kim SY , Sohn SK , Kim SG , Jin MS , Lee JO , Cheon HG , Kim SS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2622 , 2007 |
| Abstract : Ahn_2007_Bioorg.Med.Chem.Lett_17_2622 |
| ESTHER : Ahn_2007_Bioorg.Med.Chem.Lett_17_2622 |
| PubMedSearch : Ahn_2007_Bioorg.Med.Chem.Lett_17_2622 |
| PubMedID: 17331715 |
| Gene_locus related to this paper: human-DPP4 |