Cpd35-Rivastigmine-5-HT6
selective, pseudo-irreversible inhibitor of butyrylcholinesterase (IC50 = 455 nM). Inhibit aggregation of amyloid-beta in vitro 68% at 10 microM. 5-HT6R antagonist Ki 15 nM
General
Type : Derivative of Rivastigmine,Multitarget,5-HT-receptor-ligand,Sulfur Compound,Sulfonamide,Indole,Carbamate,Alkyl linked bis-ligand,anti-Abeta-aggregation
Chemical_Nomenclature : 3-(((2-((2-((1-(Phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)ethyl)amino)methyl)phenyl ethyl(methyl)carbamate
Canonical SMILES : C1(=CC=CC2=C1C=C[N]2[S](=O)(=O)C3=CC=CC=C3)OCCNCCNCC4=CC(=CC=C4)OC(=O)N(C)CC
InChI : InChI=1S\/C29H34N4O5S\/c1-3-32(2)29(34)38-24-10-7-9-23(21-24)22-31-17-16-30-18-20-37-28-14-8-13-27-26(28)15-19-33(27)39(35,36)25-11-5-4-6-12-25\/h4-15,19,21,30-31H,3,16-18,20,22H2,1-2H3
InChIKey : ICTMWXFVTKPBCM-UHFFFAOYSA-N
Other name(s) :
MW : 550.67
Formula : C29H34N4O5S
CAS_number :
PubChem :
UniChem : ICTMWXFVTKPBCM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |