Coumarin-Pyridine-3f
AChE inhibitor (IC50 = 2 nM) BuChE inhibitor activity (IC50 = 24 nM)
General
Type : Coumarin,Pyridine
Chemical_Nomenclature : 1-(3-(4-(6-Nitro-2-oxo-2H-chromen-3-yl)phenoxy) propyl)pyridinium Bromide
Canonical SMILES : C1(=CC=C2C(=C1)C=C(C(O2)=O)C3=CC=C(C=C3)OCCC[N+]4=CC=CC=C4)[N+](=O)[O-].[Br-]
InChI : InChI=1S\/C23H19N2O5.BrH\/c26-23-21(16-18-15-19(25(27)28)7-10-22(18)30-23)17-5-8-20(9-6-17)29-14-4-13-24-11-2-1-3-12-24\;\/h1-3,5-12,15-16H,4,13-14H2\;1H\/q+1\;\/p-1
InChIKey : FGLFWZQQABVJGL-UHFFFAOYSA-M
Other name(s) :
MW : 483.31
Formula : C23H19BrN2O5
CAS_number :
PubChem :
UniChem : FGLFWZQQABVJGL-UHFFFAOYSA-M
IUPHAR :
Wikipedia :
Target
Families : Coumarin-Pyridine-3f ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-ACHE || human-BCHE
References (1)
| Title : Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease - Babaei_2022_Front.Chem_10_895483 |
| Author(s) : Babaei E , Kucukkilinc TT , Jalili-Baleh L , Nadri H , Oz E , Forootanfar H , Hosseinzadeh E , Akbari T , Ardestani MS , Firoozpour L , Foroumadi A , Sharifzadeh M , Mirjalili BBF , Khoobi M |
| Ref : Front Chem , 10 :895483 , 2022 |
| Abstract : Babaei_2022_Front.Chem_10_895483 |
| ESTHER : Babaei_2022_Front.Chem_10_895483 |
| PubMedSearch : Babaei_2022_Front.Chem_10_895483 |
| PubMedID: 35844650 |