CS38
Peptide based reversible inhibitors may have a role as chaperone that could facilitate the transport of mutant PPT1 variants to the lysosome where improved enzyme stability may be observed in the lower pH environment
General
Type : Adamantyl,Triazol,Benzoate,Sulfur Compound
Chemical_Nomenclature : Methyl 2-[[2-[[5-(1-adamantyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate || methyl 2-[[2-[[5-(1-adamantyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]benzoate
Canonical SMILES : CN1C(=NN=C1SCC(=O)NC2=CC=CC=C2C(=O)OC)C34CC5CC(C3)CC(C5)C4
InChI : InChI=1S\/C23H28N4O3S\/c1-27-21(23-10-14-7-15(11-23)9-16(8-14)12-23)25-26-22(27)31-13-19(28)24-18-6-4-3-5-17(18)20(29)30-2\/h3-6,14-16H,7-13H2,1-2H3,(H,24,28)
InChIKey : JAGKTJAUMSDMOE-UHFFFAOYSA-N
Other name(s) : betaAGDap(Pal)VKIKK,CBKinase1_008064,CBKinase1_020464,ZINC16381658,BDBM91791
MW : 440.6
Formula : C23H28N4O3S
CAS_number :
PubChem : 2961124
UniChem : JAGKTJAUMSDMOE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CS38 ligand of proteins in family: Palmitoyl-protein_thioesterase
Stucture :
Protein : human-PPT1
References (1)
| Title : Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease - Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
| Author(s) : Dawson G , Schroeder C , Dawson PE |
| Ref : Biochemical & Biophysical Research Communications , 395 :66 , 2010 |
| Abstract : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
| ESTHER : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
| PubMedSearch : Dawson_2010_Biochem.Biophys.Res.Commun_395_66 |
| PubMedID: 20346914 |
| Gene_locus related to this paper: human-PPT1 |