CID155803786
ABHD17B IC50 0.13(0.11-0.16) microM ; LYPLA1 IC50 >10 microM
General
Type : Piperazine,Trifluoro,Sulfur Compound,Sulfonamide,Morpholine,Pyrazole
Chemical_Nomenclature : N,N-dimethyl-1-[(2S)-2-methyl-4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-3-sulfonamide
Canonical SMILES : CC1CN(CCN1C(=O)N2C=CC(=N2)S(=O)(=O)N(C)C)CC3=C(C=C(C=C3)C(F)(F)F)N4CCOCC4
InChI : InChI=1S\/C23H31F3N6O4S\/c1-17-15-29(8-9-31(17)22(33)32-7-6-21(27-32)37(34,35)28(2)3)16-18-4-5-19(23(24,25)26)14-20(18)30-10-12-36-13-11-30\/h4-7,14,17H,8-13,15-16H2,1-3H3\/t17-\/m0\/s1
InChIKey : GZLDKPLEYSQAJD-KRWDZBQOSA-N
Other name(s) : Compound 4 Remsberg et al.
MW : 544.6
Formula : C23H31F3N6O4S
CAS_number :
PubChem : 155803786
UniChem : GZLDKPLEYSQAJD-KRWDZBQOSA-N
IUPHAR :
Wikipedia :
Target
Families : CID155803786 ligand of proteins in family: ABHD17-depalmitoylase
Stucture :
Protein : human-ABHD17B
References (1)
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : Remsberg_2021_Nat.Chem.Biol__ |
| ESTHER : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |