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Inhibitor Report for: CID155803782

ABHD17B IC50 0.96(0.8-1.2)microM LYPLA1 IC50 0.45(0.38-0.52)microM


General
Type Piperazine, Trifluoro, Sulfur Compound, Sulfonamide, Morpholine, Pyrazole
Chemical_Nomenclature N,N-dimethyl-1-[4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-4-sulfonamide
Canonical SMILES CN(C)S(=O)(=O)C1=CN(N=C1)C(=O)N2CCN(CC2)CC3=C(C=C(C=C3)C(F)(F)F)N4CCOCC4
InChI InChI=1S/C22H29F3N6O4S/c1-27(2)36(33,34)19-14-26-31(16-19)21(32)30-7-5-28(6-8-30)15-17-3-4-18(22(23,24)25)13-20(17)29-9-11-35-12-10-29/h3-4,13-14,16H,5-12,15H2,1-2H3
InChIKey KJPLRPCRGIUKDJ-UHFFFAOYSA-N
Other name(s) Compound 2 Remsberg et al.
________________________________________________________________________________________________
MW|530.6
Formula|C22H29F3N6O4S
CAS_number|
PubChem|155803782
UniChem|KJPLRPCRGIUKDJ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | CID155803782 ligand of proteins in family: ABHD17-depalmitoylase, LYsophospholipase_carboxylesterase
Protein | human-ABHD17B, human-LYPLA1

References:
Search PubMed for references concerning: CID155803782
    Title: ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
    Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM and Cravatt BF <8 more author(s)>
    Ref: Nat Chemical Biology, :, 2021 : PubMed