CID155803778
ABHD17B IC50 0.93(0.79-1.1) LYPLA1 IC50 0.051(0.046-0.057)
General
Type : Piperazine,Sulfur Compound,Sulfonamide,Pyrazole
Chemical_Nomenclature : 1-[4-[(4-chlorophenyl)methyl]piperazine-1-carbonyl]-N,N-dimethylpyrazole-4-sulfonamide
Canonical SMILES : CN(C)S(=O)(=O)C1=CN(N=C1)C(=O)N2CCN(CC2)CC3=CC=C(C=C3)Cl
InChI : InChI=1S\/C17H22ClN5O3S\/c1-20(2)27(25,26)16-11-19-23(13-16)17(24)22-9-7-21(8-10-22)12-14-3-5-15(18)6-4-14\/h3-6,11,13H,7-10,12H2,1-2H3
InChIKey : DQMVWFRVUIAYAM-UHFFFAOYSA-N
Other name(s) : Compound 1 Remsberg et al.
MW : 411.9
Formula : C17H22ClN5O3S
CAS_number :
PubChem : 155803778
UniChem : DQMVWFRVUIAYAM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CID155803778 ligand of proteins in family: ABHD17-depalmitoylase || LYsophospholipase_carboxylesterase
Stucture :
Protein : human-ABHD17B || human-LYPLA1
References (1)
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : Remsberg_2021_Nat.Chem.Biol__ |
| ESTHER : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |