CHEMBL1086968
Stopped at phase one
General
Type : Peptide,Thiazolidine,Cyclopropyl,Indole,Sulfur Compound
Chemical_Nomenclature : [(2S,3aS,7aS)-2-(1,3-thiazolidine-3-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone
Canonical SMILES : C1CCC2C(C1)CC(N2C(=O)C3CC3C4=CC=CC=C4)C(=O)N5CCSC5
InChI : InChI=1S\/C22H28N2O2S\/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23\/h1-3,6-7,16-20H,4-5,8-14H2\/t16-,17-,18+,19-,20-\/m0\/s1
InChIKey : NXSXRIHXEQSYEZ-KNJMJIDISA-N
Other name(s) : S 17092,S-17092,SCHEMBL194654,GTPL6565,ZINC3825778
MW : 384.53
Formula : C22H28N2O2S
CAS_number : 176797-26-5
PubChem : 9929984
UniChem : NXSXRIHXEQSYEZ-KNJMJIDISA-N
IUPHAR : 6565
Wikipedia :
Target
Families : CHEMBL1086968 ligand of proteins in family: S9N_PPCE_Peptidase_S9
Stucture :
Protein : human-PREP
References (5)
| Title : Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors - |
| Author(s) : Lawandi J , Gerber-Lemaire S , Juillerat-Jeanneret L , Moitessier N |
| Ref : Journal of Medicinal Chemistry , 53 :3423 , 2010 |
| PubMedID: 20058865 |
| Title : S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies - Morain_2002_CNS.Drug.Rev_8_31 |
| Author(s) : Morain P , Lestage P , De Nanteuil G , Jochemsen R , Robin JL , Guez D , Boyer PA |
| Ref : CNS Drug Rev , 8 :31 , 2002 |
| Abstract : Morain_2002_CNS.Drug.Rev_8_31 |
| ESTHER : Morain_2002_CNS.Drug.Rev_8_31 |
| PubMedSearch : Morain_2002_CNS.Drug.Rev_8_31 |
| PubMedID: 12070525 |
| Title : Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys - Schneider_2002_Neuropsychopharmacology_26_176 |
| Author(s) : Schneider JS , Giardiniere M , Morain P |
| Ref : Neuropsychopharmacology , 26 :176 , 2002 |
| Abstract : Schneider_2002_Neuropsychopharmacology_26_176 |
| ESTHER : Schneider_2002_Neuropsychopharmacology_26_176 |
| PubMedSearch : Schneider_2002_Neuropsychopharmacology_26_176 |
| PubMedID: 11790513 |
| Title : Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study - Morain_2000_Br.J.Clin.Pharmacol_50_350 |
| Author(s) : Morain P , Robin JL , De Nanteuil G , Jochemsen R , Heidet V , Guez D |
| Ref : British Journal of Clinical Pharmacology , 50 :350 , 2000 |
| Abstract : Morain_2000_Br.J.Clin.Pharmacol_50_350 |
| ESTHER : Morain_2000_Br.J.Clin.Pharmacol_50_350 |
| PubMedSearch : Morain_2000_Br.J.Clin.Pharmacol_50_350 |
| PubMedID: 11012558 |
| Title : Novel proline endopeptidase inhibitors do not modify Abeta40\/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein - Petit_2000_Br.J.Pharmacol_130_1613 |
| Author(s) : Petit A , Barelli H , Morain P , Checler F |
| Ref : British Journal of Pharmacology , 130 :1613 , 2000 |
| Abstract : Petit_2000_Br.J.Pharmacol_130_1613 |
| ESTHER : Petit_2000_Br.J.Pharmacol_130_1613 |
| PubMedSearch : Petit_2000_Br.J.Pharmacol_130_1613 |
| PubMedID: 10928965 |