C18-octadecyl-MAG-like-phosphonate
mimics the Monoacylglycerol MAG of identical size (here the Eicosanoic acid (C20:0). The adduct on the active serine lacks the leaving group 4-nitrophenol
General
Type : Organophosphate,Analogue of substrate,Lipase inhibitor,pNP,Azido
Chemical_Nomenclature : imino-[3-[octadecoxy(oxo)phosphaniumyl]propylimino]azanium
Canonical SMILES : CCCCCCCCCCCCCCCCCCO[P+](=O)CCCN=[N+]=N
InChI : InChI=1S\/C21H44N3O2P\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-26-27(25)21-18-19-23-24-22\/h22H,2-21H2,1H3\/q+2
InChIKey : HBEQQGDNWMLVMF-UHFFFAOYSA-N
Other name(s) : 1-{3-[(R)-hydroxy(octadecyloxy)phosphoryl]propyl}triaza-1,2-dien-2-ium,octadecyl hydrogen (R)-(3-azidopropyl)phosphonate,3-[octadecoxy(hydroxy)phosphoryl]propylimino-iminoazanium
MW : 401.57
Formula : C21H44N3O2P+2
CAS_number :
PubChem : 119057444
UniChem : HBEQQGDNWMLVMF-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : C18-octadecyl-MAG-like-phosphonate ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture : 4ZXF Crystal structure of a soluble variant of Monoglyceride Lipase (Yju3p) from Saccharomyces Cerevisiae in complex with a substrate analog
Protein : yeast-mgll
References (2)
| Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016 |
| Abstract : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| ESTHER : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| PubMedSearch : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| PubMedID: 26869448 |
| Gene_locus related to this paper: yeast-mgll |
| Title : Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae - Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| Author(s) : Rengachari S , Aschauer P , Sturm C , Oberer M |
| Ref : Acta Crystallographica F Struct Biol Commun , 71 :243 , 2015 |
| Abstract : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| ESTHER : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| PubMedSearch : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
| PubMedID: 25664804 |
| Gene_locus related to this paper: yeast-mgll |