Antipain
Antipain is an oligopeptide produced by various bacteria which acts as a protease inhibitor
General
Type : Peptide
Chemical_Nomenclature : 2-[[5-(diaminomethylideneamino)-1-[[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoylamino]-3-phenylpropanoic acid
Canonical SMILES : CC(C)C(C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C(CCCN=C(N)N)NC(=O)NC(CC1=CC=CC=C1)C(=O)O
InChI : InChI=1S\/C27H44N10O6\/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17\/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)
InChIKey : SDNYTAYICBFYFH-UHFFFAOYSA-N
Other name(s) : AC1L1D5R,SCHEMBL14038024,HMS3369O02,[(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal,VAL,ARG,FC0,OAR,PRD_000180
MW : 604.70
Formula : C27H44N10O6
CAS_number : 37691-11-5
PubChem : 2205
UniChem : SDNYTAYICBFYFH-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Antipain
Target
Families : Antipain ligand of proteins in family: S9N_PREPL_Peptidase_S9 || Carboxypeptidase_S10
Stucture :
Protein : trybr-PEPTB || leima-OPB || wheat-cbp02
References (3)
| Title : Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes - Canning_2013_PLoS.One_8_e79349 |
| Author(s) : Canning P , Rea D , Morty RE , Fulop V |
| Ref : PLoS ONE , 8 :e79349 , 2013 |
| Abstract : Canning_2013_PLoS.One_8_e79349 |
| ESTHER : Canning_2013_PLoS.One_8_e79349 |
| PubMedSearch : Canning_2013_PLoS.One_8_e79349 |
| PubMedID: 24265767 |
| Gene_locus related to this paper: trybr-PEPTB |
| Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249 |
| Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC |
| Ref : Journal of Biological Chemistry , 285 :39249 , 2010 |
| Abstract : McLuskey_2010_J.Biol.Chem_285_39249 |
| ESTHER : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedID: 20926390 |
| Gene_locus related to this paper: leima-OPB |
| Title : Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity - Bullock_1996_J.Mol.Biol_255_714 |
| Author(s) : Bullock TL , Breddam K , Remington SJ |
| Ref : Journal of Molecular Biology , 255 :714 , 1996 |
| Abstract : Bullock_1996_J.Mol.Biol_255_714 |
| ESTHER : Bullock_1996_J.Mol.Biol_255_714 |
| PubMedSearch : Bullock_1996_J.Mol.Biol_255_714 |
| PubMedID: 8636973 |
| Gene_locus related to this paper: wheat-cbp02 |