1. Home
  2. Inhibitor
  3. AM3506

AM3506

Inhibitor of FAAH (not alpha/beta hydrolase) IC50 2.4 nM; but not so bad MGLL inhibitor IC50 236nM

General

Type : FAAH inhibitor,Sulfur Compound,Sulfonyl

Chemical_Nomenclature : 5-(4-hydroxyphenyl)pentane-1-sulfonyl fluoride

Canonical SMILES : C1=CC(=CC=C1CCCCCS(=O)(=O)F)O

InChI : InChI=1S\/C11H15FO3S\/c12-16(14,15)9-3-1-2-4-10-5-7-11(13)8-6-10\/h5-8,13H,1-4,9H2

InChIKey : VCCAJGFVUCFGSD-UHFFFAOYSA-N

Other name(s) : CHEMBL2180821,5-(4-Hydroxyphenyl)Pentanesulfonyl Fluoride,AM-3506,SCHEMBL1171639,BDBM50399280

MW : 246.30

Formula : C11H15FO3S

CAS_number :

PubChem : 25017608

UniChem : VCCAJGFVUCFGSD-UHFFFAOYSA-N

Target

Families : AM3506 ligand of proteins in family
Monoglyceridelipase_lysophospholip

References (1)

Title : Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats - Panlilio_2016_Psychopharmacology.(Berl)_233_1879
Author(s) : Panlilio LV , Thorndike EB , Nikas SP , Alapafuja SO , Bandiera T , Cravatt BF , Makriyannis A , Piomelli D , Goldberg SR , Justinova Z
Ref : Psychopharmacology (Berl) , 233 :1879 , 2016
Abstract : Panlilio_2016_Psychopharmacology.(Berl)_233_1879
ESTHER : Panlilio_2016_Psychopharmacology.(Berl)_233_1879
PubMedSearch : Panlilio_2016_Psychopharmacology.(Berl)_233_1879
PubMedID: 26558620 
Array
(
    [id] => 3879
    [inhibitor] => AM3506
    [type] => Array
        (
            [0] => FAAH inhibitor
            [1] => Sulfur Compound
            [2] => Sulfonyl
        )

    [other_name] => Array
        (
            [0] => CHEMBL2180821
            [1] => 5-(4-Hydroxyphenyl)Pentanesulfonyl Fluoride
            [2] => AM-3506
            [3] => SCHEMBL1171639
            [4] => BDBM50399280
        )

    [chemical_nomenclature] => 5-(4-hydroxyphenyl)pentane-1-sulfonyl fluoride
    [formula] => C11H15FO3S
    [cas_number] => 
    [mw] => 246.30
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Panlilio_2016_Psychopharmacology.(Berl)_233_1879
    [comment] => Inhibitor of FAAH (not alpha\/beta hydrolase) IC50 2.4 nM\;  but not so bad MGLL inhibitor IC50 236nM
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 25017608
    [family] => Monoglyceridelipase_lysophospholip
    [inchikey] => VCCAJGFVUCFGSD-UHFFFAOYSA-N
    [canonicalsmiles] => C1=CC(=CC=C1CCCCCS(=O)(=O)F)O
    [inchi] => InChI=1S\/C11H15FO3S\/c12-16(14,15)9-3-1-2-4-10-5-7-11(13)8-6-10\/h5-8,13H,1-4,9H2
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)