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AI0-7QBQ

General

Type : Quinoline,Multitarget,Monoamine-oxidase-inhibitor

Chemical_Nomenclature : 1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine oxide

Canonical SMILES : c1ccc(cc1)C\/[N+](=C\/c2ccc3cccc(c3n2)O)\/[O-]

InChI : InChI=1S\/C17H14N2O2\/c20-16-8-4-7-14-9-10-15(18-17(14)16)12-19(21)11-13-5-2-1-3-6-13\/h1-10,12,20H,11H2\/b19-12-

InChIKey : SHXQVJVENHOUOF-UNOMPAQXSA-N

Other name(s) : (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide,1-(8-oxidanylquinolin-2-yl)-~{N}-(phenylmethyl)methanimine oxide,Quinolylnitrone 19,QN19

MW : 278.31

Formula : C17H14N2O2

CAS_number :

PubChem :

UniChem : SHXQVJVENHOUOF-UNOMPAQXSA-N

IUPHAR :

Wikipedia :

Target

Families : AI0-7QBQ ligand of proteins in family: BCHE

Stucture : 7QBQ Human butyrylcholinesterase in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide

Protein :

References (1)

Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J
Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023
Abstract : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
ESTHER : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
PubMedID: 37250172
Gene_locus related to this paper: human-BCHE