AA39-2 (compound 21) completely blocked PAFAH2 activity at 10 nM, while not inhibiting ABHD11, APEH, LYPLA1, or other SHs in T-cells at 100 nM
Type : Triazol,Pyrrolidine
Chemical_Nomenclature : [4-(4-phenylphenyl)triazol-1-yl]-pyrrolidin-1-ylmethanone
Canonical SMILES : C1CCN(C1)C(=O)N2C=C(N=N2)C3=CC=C(C=C3)C4=CC=CC=C4
InChI : InChI=1S\/C19H18N4O\/c24-19(22-12-4-5-13-22)23-14-18(20-21-23)17-10-8-16(9-11-17)15-6-2-1-3-7-15\/h1-3,6-11,14H,4-5,12-13H2
InChIKey : NEKZEBMUYCZCTC-UHFFFAOYSA-N
Other name(s) : compound 21,CHEBI:93336,Q27165048
MW : 318.4
Formula : C19H18N4O
CAS_number : 1312782-40-3
PubChem : 49837819
UniChem : NEKZEBMUYCZCTC-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : AA39-2 ligand of proteins in family: PAF-Acetylhydrolase
Stucture :
Protein : human-PAFAH2
Title : Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation - Shimanaka_2017_Nat.Med_23_1287 |
Author(s) : Shimanaka Y , Kono N , Taketomi Y , Arita M , Okayama Y , Tanaka Y , Nishito Y , Mochizuki T , Kusuhara H , Adibekian A , Cravatt BF , Murakami M , Arai H |
Ref : Nat Med , 23 :1287 , 2017 |
Abstract : Shimanaka_2017_Nat.Med_23_1287 |
ESTHER : Shimanaka_2017_Nat.Med_23_1287 |
PubMedSearch : Shimanaka_2017_Nat.Med_23_1287 |
PubMedID: 29035365 |
Gene_locus related to this paper: human-PAFAH2 |
Title : Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors - Adibekian_2011_Nat.Chem.Biol_7_469 |
Author(s) : Adibekian A , Martin BR , Wang C , Hsu KL , Bachovchin DA , Niessen S , Hoover H , Cravatt BF |
Ref : Nat Chemical Biology , 7 :469 , 2011 |
Abstract : Adibekian_2011_Nat.Chem.Biol_7_469 |
ESTHER : Adibekian_2011_Nat.Chem.Biol_7_469 |
PubMedSearch : Adibekian_2011_Nat.Chem.Biol_7_469 |
PubMedID: 21572424 |