76-0079
IC50 0.184 microM LIPE - lipase E, hormone sensitive type
General
Type : Morpholine
Chemical_Nomenclature : (4-chlorophenyl) N-morpholin-4-ylcarbamate
Canonical SMILES : C1COCCN1NC(=O)OC2=CC=C(C=C2)Cl
InChI : InChI=1S\/C11H13ClN2O3\/c12-9-1-3-10(4-2-9)17-11(15)13-14-5-7-16-8-6-14\/h1-4H,5-8H2,(H,13,15)
InChIKey : CJKVBAQMCNYASH-UHFFFAOYSA-N
Other name(s) : CHEMBL291207,Morpholin-4-yl-carbamic acid 4-chloro-phenyl ester,SCHEMBL7550336,BDBM50142723,76-0079,NNC 0076-0000-0079,NNC0076-0079
MW : 256.68
Formula : C11H13ClN2O3
CAS_number :
PubChem : 9856441
UniChem : CJKVBAQMCNYASH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (5)
| Title : Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation - Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730 |
| Author(s) : Wagner C , Hois V , Pajed L , Pusch LM , Wolinski H , Trauner M , Zimmermann R , Taschler U , Lass A |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1865 :158730 , 2020 |
| Abstract : Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730 |
| ESTHER : Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730 |
| PubMedSearch : Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730 |
| PubMedID: 32361002 |
| Gene_locus related to this paper: human-LIPA |
| Title : Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages - Sakai_2014_J.Lipid.Res_55_2033 |
| Author(s) : Sakai K , Igarashi M , Yamamuro D , Ohshiro T , Nagashima S , Takahashi M , Enkhtuvshin B , Sekiya M , Okazaki H , Osuga J , Ishibashi S |
| Ref : J Lipid Res , 55 :2033 , 2014 |
| Abstract : Sakai_2014_J.Lipid.Res_55_2033 |
| ESTHER : Sakai_2014_J.Lipid.Res_55_2033 |
| PubMedSearch : Sakai_2014_J.Lipid.Res_55_2033 |
| PubMedID: 24868095 |
| Title : Resveratrol regulates lipolysis via adipose triglyceride lipase - Lasa_2012_J.Nutr.Biochem_23_379 |
| Author(s) : Lasa A , Schweiger M , Kotzbeck P , Churruca I , Simon E , Zechner R , Portillo MP |
| Ref : J Nutr Biochem , 23 :379 , 2012 |
| Abstract : Lasa_2012_J.Nutr.Biochem_23_379 |
| ESTHER : Lasa_2012_J.Nutr.Biochem_23_379 |
| PubMedSearch : Lasa_2012_J.Nutr.Biochem_23_379 |
| PubMedID: 21543206 |
| Title : Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training - Alsted_2009_Am.J.Physiol.Endocrinol.Metab_296_E445 |
| Author(s) : Alsted TJ , Nybo L , Schweiger M , Fledelius C , Jacobsen P , Zimmermann R , Zechner R , Kiens B |
| Ref : American Journal of Physiology Endocrinol Metab , 296 :E445 , 2009 |
| Abstract : Alsted_2009_Am.J.Physiol.Endocrinol.Metab_296_E445 |
| ESTHER : Alsted_2009_Am.J.Physiol.Endocrinol.Metab_296_E445 |
| PubMedSearch : Alsted_2009_Am.J.Physiol.Endocrinol.Metab_296_E445 |
| PubMedID: 19106247 |
| Title : Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism - Schweiger_2006_J.Biol.Chem_281_40236 |
| Author(s) : Schweiger M , Schreiber R , Haemmerle G , Lass A , Fledelius C , Jacobsen P , Tornqvist H , Zechner R , Zimmermann R |
| Ref : Journal of Biological Chemistry , 281 :40236 , 2006 |
| Abstract : Schweiger_2006_J.Biol.Chem_281_40236 |
| ESTHER : Schweiger_2006_J.Biol.Chem_281_40236 |
| PubMedSearch : Schweiger_2006_J.Biol.Chem_281_40236 |
| PubMedID: 17074755 |