6M06-BWF
General
Type : Pyrrolidine
Chemical_Nomenclature : (2S)-2-[(Z)-2-carboxy-1-hydroxyethenyl]pyrrolidine-1-carboxylic acid
Canonical SMILES : C1CC(N(C1)C(=O)O)C(=CC(=O)O)O
InChI : InChI=1S\/C8H11NO5\/c10-6(4-7(11)12)5-2-1-3-9(5)8(13)14\/h4-5,10H,1-3H2,(H,11,12)(H,13,14)\/b6-4-\/t5-\/m0\/s1
InChIKey : ROSCYVZNGZEOEY-YIWIKUPCSA-N
Other name(s) : (Z)-3-[(2S)-1-methanoylpyrrolidin-2-yl]-3-oxidanyl-prop-2-enoic acid,(2S)-2-[(Z)-1,3-bis(oxidanyl)-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid,BWF,Compound 5
MW : 201.18
Formula : C8H11NO5
CAS_number :
PubChem : 155289214
UniChem : ROSCYVZNGZEOEY-YIWIKUPCSA-N
IUPHAR :
Wikipedia :
Target
Families : 6M06-BWF ligand of proteins in family: PAF-Acetylhydrolase
Stucture : 6M06 Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M06-BWF Compound 5
Protein : human-PLA2G7
References (1)
| Title : Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach - Huang_2020_J.Med.Chem_63_7052 |
| Author(s) : Huang F , Hu H , Wang K , Peng C , Xu W , Zhang Y , Gao J , Liu Y , Zhou H , Huang R , Li M , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 63 :7052 , 2020 |
| Abstract : Huang_2020_J.Med.Chem_63_7052 |
| ESTHER : Huang_2020_J.Med.Chem_63_7052 |
| PubMedSearch : Huang_2020_J.Med.Chem_63_7052 |
| PubMedID: 32459096 |
| Gene_locus related to this paper: human-PLA2G7 |