10c-Salicylimine-Tacrine
IC50 0.0826 microM (AChE) and 0.0156 microM (BChE)
General
Type : Acridine,Derivative of Tacrine,Salicylic,Alkyl linked bis-ligand
Chemical_Nomenclature :
Canonical SMILES : [C]2=[C]C1=NC4=C(C(=C1[C]=[C]2)[N]CCCCCCCCN=[C]C3=[C][C]=[C][C]=C3[O])CCCC4
InChI : InChI=1S\/C28H35N3O\/c32-27-18-10-5-13-22(27)21-29-19-11-3-1-2-4-12-20-30-28-23-14-6-8-16-25(23)31-26-17-9-7-15-24(26)28\/h5-6,8,10,13-14,16,18,21,32H,1-4,7,9,11-12,15,17,19-20H2,(H,30,31)
InChIKey : INQWNLSYQXSCDQ-UHFFFAOYSA-N
Other name(s) :
MW : 429.60
Formula : C28H35N3O
CAS_number :
PubChem :
UniChem : INQWNLSYQXSCDQ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : 10c-Salicylimine-Tacrine ligand of proteins in family: BCHE
Stucture :
Protein : human-BCHE
References (1)
| Title : Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease - Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Grishchenko MV , Lushchekina SV , Astakhova TY , Serebryakova OG , Timokhina EN , Zhilina EF , Shchegolkov EV , Ulitko MV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
| Ref : Int J Mol Sci , 24 :2285 , 2023 |
| Abstract : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| ESTHER : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| PubMedSearch : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| PubMedID: 36768608 |