torca-ACHE
Torpedo californica (Tetronarce californica) (Pacific electric ray) (Torpedo californica) acetylcholinesterase
Comment
Acetylcholinesterase (ACHE\; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly || Alternate Cterminus: T or H peptide
Relationship
Molecular evidence
No mutation
1AMN
1ACJ
2ACK
1ACL
1FSS
1VOT
2ACE
1EVE
1OCE
1AX9
2DFP
1SOM
1VXO
1VXR
1QID
1QIE
1QIF
1QIG
1QIH
1QII
1QIJ
1QIK
1QIM
1CFJ
1QTI
1DX6
1E3Q
1EA5
1E66
1HBJ
1JJB
7AIT
7AIS
7AIU
7AIV
7AIW
7AIX
7B38
7B8E
7B2W
7AJ1
7AJ3
6TT0
6H12
6H13
6H14
6G17
6FQN
6G4P
6G4O
6G4N
6G4M
6G1W
6G1V
6G1U
6FLD
6EWK
6EUC
6EUE
6EZG
6EZH
5NUU
5NAP
5NAU
5IH7
5EHX
5EI5
5BWB
5BWC
4X3C
4W63
4TVK
3ZV7
2XI4
3M3D
3I6M
3I6Z
2WFZ
2WG0
2WG1
2WG2
3GEL
2W6C
5E4J
5E4T
5DLP
5E2I
2VT6
2VT7
2VQ6
2VJA
2VJB
2VJC
2VJD
2VA9
2V96
2V97
2V98
2J4F
2J3D
2J3Q
2CMF
2CKM
2CEK
2C4H
2C58
2C5G
2C5F
2BAG
1GPK
1GPN
1GQR
1GQS
1H22
1H23
1ODC
1U65
1UT6
1VZJ
1W4L
1W6R
1W75
1W76
1ZGB
1ZGC
No disease
8U2-7AIX7AY-compound5i
8U5-7AIW-compound5g
8UE-7AIV-compound5f
8UQ-7AIU-compound5d
8UK-7AIT-compound5c
8UH-7AIS-compound5b
MC1420
6H12-(R)2
6H13-(R)3
6H14-(S)6
Sigma1R-ACHE-6a
Sigma1R-ACHE-6b
Chlorotacrine-tryptophan-hybrid
Donepezil-derivative-DZ7
Donepezil-derivative-DZ0
E0Z
E1K
E1N
1-methylindol-3-one
N-piperidinopropylgalanthamine
N-saccharinohexylgalanthamine
bis9-(-)-nor-meptazinol
Nitrophenyl-trifluoroethyl-arsenocholine
Diethylene-glycol
Triethylene-glycol
PEG-SH-350
Tacrine-nicotinamide
Methylene-blue
Tacrine(8)-4-aminoquinoline
NBD-AE-MPF
NBD-P-MPF
NBD-AP-MPF
Thioflavin-T
Aroylacrylic-acid-amide-Tacrine-10
NF595
Aflatoxin-B1
Bis-Noreseroline
Phthalimido-Galanthaminium-4d
Bisnorcymserine
NAP
FBQ
Ganstigmine
N-ammoniooctyl-tacrine
Aricept~Donepezil~E2020
Tacrine-Benzofuran
Chlorotacrine-juglone
Bis5-tacrine
Bis7-tacrine
BW284C51
4-hydroxy-N,N,N-trimethylpentanaminium
4-oxo-N,N,N-trimethylpentanaminium
Decamethonium
Edrophonium
ENA-713~Rivastigmine
Galanthamine
HuperzineA
HuperzineB
HuprineX
NEDPA
Methylparaoxon
MF268
MSF
Soman
Tacrine
(R)-Tacrine(10)-Hupyridone
(S,S)-(-)-bis(12)-hupyridone
(S,S)-(-)-bis(10)-hupyridone
NAF
TMTFA
VX
Tacrine-pyridinealdoxime-1
Sequence
Peptide
DDHSELLVNT KSGKVMGTRV PVLSSHISAF LGIPFAEPPV GNMRFRRPEP KKPWSGVWNA STYPNNCQQY VDEQFPGFSG SEMWNPNREM SEDCLYLNIW VPSPRPKSTT VMVWIYGGGF YSGSSTLDVY NGKYLAYTEE VVLVSLSYRV GAFGFLALHG SQEAPGNVGL LDQRMALQWV HDNIQFFGGD PKTVTIFGES AGGASVGMHI LSPGSRDLFR RAILQSGSPN CPWASVSVAE GRRRAVELGR NLNCNLNSDE ELIHCLREKK PQELIDVEWN VLPFDSIFRF SFVPVIDGEF FPTSLESMLN SGNFKKTQIL LGVNKDEGSF FLLYGAPGFS KDSESKISRE DFMSGVKLSV PHANDLGLDA VTLQYTDWMD DNNGIKNRDG LDDIVGDHNV ICPLMHFVNK YTKFGNGTYL YFFNHRASNL VWPEWMGVIH GYEIEFVFGL PLVKELNYTA EEEALSRRIM HYWATFAKTG NPNEPHSQES KWPLFTTKEQ KFIDLNTEPM KVHQRLRVQM CVFWNQFLPK LLNATETIDE AERQWKTEFH RWSSYMMHWK NQFDHYSRHE SCAEL
References
| Title : Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif - Silman_2021_Protein.Sci_30_966 |
| Author(s) : Silman I , Shnyrov VL , Ashani Y , Roth E , Nicolas A , Sussman JL , Weiner L |
| Ref : Protein Science , 30 :966 , 2021 |
| Abstract : Silman_2021_Protein.Sci_30_966 |
| ESTHER : Silman_2021_Protein.Sci_30_966 |
| PubMedSearch : Silman_2021_Protein.Sci_30_966 |
| PubMedID: 33686648 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY |
| Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019 |
| Abstract : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| ESTHER : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedSearch : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedID: 30798053 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. - Dighe_2019_Commun.Chem_2_35 |
| Author(s) : Dighe SN , De la Mora E , Chan S , Kantham S , McColl G , Miles JA , Veliyath SK , Sreenivas BY , Nassar ZD , Silman I , Sussman JL , Weik M , McGeary RP , Parat MO , Brazzolotto X , Ross BP |
| Ref : Communications chemistry , 2 :35 , 2019 |
| Abstract : Dighe_2019_Commun.Chem_2_35 |
| ESTHER : Dighe_2019_Commun.Chem_2_35 |
| PubMedSearch : Dighe_2019_Commun.Chem_2_35 |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE , torca-ACHE |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234 |
| Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019 |
| Abstract : Lalut_2019_Eur.J.Med.Chem_162_234 |
| ESTHER : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedID: 30447434 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630 |
| Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F |
| Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018 |
| Abstract : Santoni_2018_J.Med.Chem_61_7630 |
| ESTHER : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedSearch : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedID: 30125110 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : Zorbaz_2018_Chemistry_24_9675 |
| ESTHER : Zorbaz_2018_Chemistry_24_9675 |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues - Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| Author(s) : Caliandro R , Pesaresi A , Cariati L , Procopio A , Oliverio M , Lamba D |
| Ref : J Enzyme Inhib Med Chem , 33 :794 , 2018 |
| Abstract : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| ESTHER : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| PubMedSearch : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| PubMedID: 29651884 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114 |
| Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M |
| Ref : Journal of Medicinal Chemistry , 59 :114 , 2016 |
| Abstract : Zha_2016_J.Med.Chem_59_114 |
| ESTHER : Zha_2016_J.Med.Chem_59_114 |
| PubMedSearch : Zha_2016_J.Med.Chem_59_114 |
| PubMedID: 26632651 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue\/Acetylcholinesterase Complex - Dym_2016_Protein.Sci_25_1096 |
| Author(s) : Dym O , Song W , Felder CE , Roth E , Shnyrov V , Ashani Y , Xu Y , Joosten RP , Weiner L , Sussman JL , Silman I |
| Ref : Protein Science , 25 :1096 , 2016 |
| Abstract : Dym_2016_Protein.Sci_25_1096 |
| ESTHER : Dym_2016_Protein.Sci_25_1096 |
| PubMedSearch : Dym_2016_Protein.Sci_25_1096 |
| PubMedID: 26990888 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime - Legler_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_1788 |
| Author(s) : Legler PM , Soojhawon I , Millard CB |
| Ref : Acta Crystallographica D Biol Crystallogr , 71 :1788 , 2015 |
| Abstract : Legler_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_1788 |
| ESTHER : Legler_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_1788 |
| PubMedSearch : Legler_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_1788 |
| PubMedID: 26327369 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576 |
| Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014 |
| Abstract : Nepovimova_2014_J.Med.Chem_57_8576 |
| ESTHER : Nepovimova_2014_J.Med.Chem_57_8576 |
| PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576 |
| PubMedID: 25259726 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase - Paz_2012_Protein.Sci_21_1138 |
| Author(s) : Paz A , Roth E , Ashani Y , Xu Y , Shnyrov VL , Sussman JL , Silman I , Weiner L |
| Ref : Protein Science , 21 :1138 , 2012 |
| Abstract : Paz_2012_Protein.Sci_21_1138 |
| ESTHER : Paz_2012_Protein.Sci_21_1138 |
| PubMedSearch : Paz_2012_Protein.Sci_21_1138 |
| PubMedID: 22674800 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations - Sanson_2011_Protein.Sci_20_1114 |
| Author(s) : Sanson B , Colletier JP , Xu Y , Lang PT , Jiang H , Silman I , Sussman JL , Weik M |
| Ref : Protein Science , 20 :1114 , 2011 |
| Abstract : Sanson_2011_Protein.Sci_20_1114 |
| ESTHER : Sanson_2011_Protein.Sci_20_1114 |
| PubMedSearch : Sanson_2011_Protein.Sci_20_1114 |
| PubMedID: 21594947 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives - Bartolucci_2010_J.Med.Chem_53_745 |
| Author(s) : Bartolucci C , Haller LA , Jordis U , Fels G , Lamba D |
| Ref : Journal of Medicinal Chemistry , 53 :745 , 2010 |
| Abstract : Bartolucci_2010_J.Med.Chem_53_745 |
| ESTHER : Bartolucci_2010_J.Med.Chem_53_745 |
| PubMedSearch : Bartolucci_2010_J.Med.Chem_53_745 |
| PubMedID: 20025280 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad - Paz_2009_J.Med.Chem_52_2543 |
| Author(s) : Paz A , Xie Q , Greenblatt HM , Fu W , Tang Y , Silman I , Qiu Z , Sussman JL |
| Ref : Journal of Medicinal Chemistry , 52 :2543 , 2009 |
| Abstract : Paz_2009_J.Med.Chem_52_2543 |
| ESTHER : Paz_2009_J.Med.Chem_52_2543 |
| PubMedSearch : Paz_2009_J.Med.Chem_52_2543 |
| PubMedID: 19326912 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593 |
| Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M |
| Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009 |
| Abstract : Sanson_2009_J.Med.Chem_52_7593 |
| ESTHER : Sanson_2009_J.Med.Chem_52_7593 |
| PubMedSearch : Sanson_2009_J.Med.Chem_52_7593 |
| PubMedID: 19642642 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site - Harel_2008_J.Am.Chem.Soc_130_7856 |
| Author(s) : Harel M , Sonoda LK , Silman I , Sussman JL , Rosenberry TL |
| Ref : Journal of the American Chemical Society , 130 :7856 , 2008 |
| Abstract : Harel_2008_J.Am.Chem.Soc_130_7856 |
| ESTHER : Harel_2008_J.Am.Chem.Soc_130_7856 |
| PubMedSearch : Harel_2008_J.Am.Chem.Soc_130_7856 |
| PubMedID: 18512913 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography - Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| Author(s) : Colletier JP , Bourgeois D , Sanson B , Fournier D , Sussman JL , Silman I , Weik M |
| Ref : Proc Natl Acad Sci U S A , 105 :11742 , 2008 |
| Abstract : Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| ESTHER : Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| PubMedSearch : Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| PubMedID: 18701720 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography - Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| Author(s) : Colletier JP , Royant A , Specht A , Sanson B , Nachon F , Masson P , Zaccai G , Sussman JL , Goeldner M , Silman I , Bourgeois D , Weik M |
| Ref : Acta Crystallographica D Biol Crystallogr , 63 :1115 , 2007 |
| Abstract : Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| ESTHER : Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| PubMedSearch : Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| PubMedID: 18007027 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) - Bartolucci_2006_J.Med.Chem_49_5051 |
| Author(s) : Bartolucci C , Siotto M , Ghidini E , Amari G , Bolzoni PT , Racchi M , Villetti G , Delcanale M , Lamba D |
| Ref : Journal of Medicinal Chemistry , 49 :5051 , 2006 |
| Abstract : Bartolucci_2006_J.Med.Chem_49_5051 |
| ESTHER : Bartolucci_2006_J.Med.Chem_49_5051 |
| PubMedSearch : Bartolucci_2006_J.Med.Chem_49_5051 |
| PubMedID: 16913695 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491 |
| Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL |
| Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006 |
| Abstract : Rydberg_2006_J.Med.Chem_49_5491 |
| ESTHER : Rydberg_2006_J.Med.Chem_49_5491 |
| PubMedSearch : Rydberg_2006_J.Med.Chem_49_5491 |
| PubMedID: 16942022 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor - Colletier_2006_J.Am.Chem.Soc_128_4526 |
| Author(s) : Colletier JP , Sanson B , Nachon F , Gabellieri E , Fattorusso C , Campiani G , Weik M |
| Ref : Journal of the American Chemical Society , 128 :4526 , 2006 |
| Abstract : Colletier_2006_J.Am.Chem.Soc_128_4526 |
| ESTHER : Colletier_2006_J.Am.Chem.Soc_128_4526 |
| PubMedSearch : Colletier_2006_J.Am.Chem.Soc_128_4526 |
| PubMedID: 16594661 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structural insights into substrate traffic and inhibition in acetylcholinesterase - Colletier_2006_EMBO.J_25_2746 |
| Author(s) : Colletier JP , Fournier D , Greenblatt HM , Stojan J , Sussman JL , Zaccai G , Silman I , Weik M |
| Ref : EMBO Journal , 25 :2746 , 2006 |
| Abstract : Colletier_2006_EMBO.J_25_2746 |
| ESTHER : Colletier_2006_EMBO.J_25_2746 |
| PubMedSearch : Colletier_2006_EMBO.J_25_2746 |
| PubMedID: 16763558 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase - Harel_2005_Chem.Biol.Interact_157-158_153 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :153 , 2005 |
| Abstract : Harel_2005_Chem.Biol.Interact_157-158_153 |
| ESTHER : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedSearch : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedID: 16289500 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action - Harel_2005_Mol.Pharmacol_67_1874 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Yoon KJ , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Molecular Pharmacology , 67 :1874 , 2005 |
| Abstract : Harel_2005_Mol.Pharmacol_67_1874 |
| ESTHER : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedSearch : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedID: 15772291 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase - Haviv_2005_J.Am.Chem.Soc_127_11029 |
| Author(s) : Haviv H , Wong DM , Greenblatt HM , Carlier PR , Pang YP , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 127 :11029 , 2005 |
| Abstract : Haviv_2005_J.Am.Chem.Soc_127_11029 |
| ESTHER : Haviv_2005_J.Am.Chem.Soc_127_11029 |
| PubMedSearch : Haviv_2005_J.Am.Chem.Soc_127_11029 |
| PubMedID: 16076210 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix - Dvir_2004_EMBO.J_23_4394 |
| Author(s) : Dvir H , Harel M , Bon S , Liu WQ , Vidal M , Garbay C , Sussman JL , Massoulie J , Silman I |
| Ref : EMBO Journal , 23 :4394 , 2004 |
| Abstract : Dvir_2004_EMBO.J_23_4394 |
| ESTHER : Dvir_2004_EMBO.J_23_4394 |
| PubMedSearch : Dvir_2004_EMBO.J_23_4394 |
| PubMedID: 15526038 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design - Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| Author(s) : Greenblatt HM , Guillou C , Guenard D , Argaman A , Botti SA , Badet B , Thal C , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 126 :15405 , 2004 |
| Abstract : Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| ESTHER : Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| PubMedSearch : Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| PubMedID: 15563167 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity - Wong_2003_J.Am.Chem.Soc_125_363 |
| Author(s) : Wong DM , Greenblatt HM , Dvir H , Carlier PR , Han YF , Pang YP , Silman I , Sussman JL |
| Ref : J Am Chem Soc , 125 :363 , 2003 |
| Abstract : Wong_2003_J.Am.Chem.Soc_125_363 |
| ESTHER : Wong_2003_J.Am.Chem.Soc_125_363 |
| PubMedSearch : Wong_2003_J.Am.Chem.Soc_125_363 |
| PubMedID: 12517147 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine - Bar-On_2002_Biochemistry_41_3555 |
| Author(s) : Bar-On P , Millard CB , Harel M , Dvir H , Enz A , Sussman JL , Silman I |
| Ref : Biochemistry , 41 :3555 , 2002 |
| Abstract : Bar-On_2002_Biochemistry_41_3555 |
| ESTHER : Bar-On_2002_Biochemistry_41_3555 |
| PubMedSearch : Bar-On_2002_Biochemistry_41_3555 |
| PubMedID: 11888271 |
| Gene_locus related to this paper: torca-ACHE |
| Title : 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates - Dvir_2002_Biochemistry_41_2970 |
| Author(s) : Dvir H , Wong DM , Harel M , Barril X , Orozco M , Luque FJ , Munoz-Torrero D , Camps P , Rosenberry TL , Silman I , Sussman JL |
| Ref : Biochemistry , 41 :2970 , 2002 |
| Abstract : Dvir_2002_Biochemistry_41_2970 |
| ESTHER : Dvir_2002_Biochemistry_41_2970 |
| PubMedSearch : Dvir_2002_Biochemistry_41_2970 |
| PubMedID: 11863435 |
| Gene_locus related to this paper: torca-ACHE |
| Title : X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement - Dvir_2002_Biochemistry_41_10810 |
| Author(s) : Dvir H , Jiang H , Wong DM , Harel M , Chetrit M , He XC , Jin GY , Yu GL , Tang XC , Silman I , Bai DL , Sussman JL |
| Ref : Biochemistry , 41 :10810 , 2002 |
| Abstract : Dvir_2002_Biochemistry_41_10810 |
| ESTHER : Dvir_2002_Biochemistry_41_10810 |
| PubMedSearch : Dvir_2002_Biochemistry_41_10810 |
| PubMedID: 12196020 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase - Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| Author(s) : Felder CE , Harel M , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 58 :1765 , 2002 |
| Abstract : Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| ESTHER : Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| PubMedSearch : Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| PubMedID: 12351819 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica - Koellner_2002_J.Mol.Biol_320_721 |
| Author(s) : Koellner G , Steiner T , Millard CB , Silman I , Sussman JL |
| Ref : Journal of Molecular Biology , 320 :721 , 2002 |
| Abstract : Koellner_2002_J.Mol.Biol_320_721 |
| ESTHER : Koellner_2002_J.Mol.Biol_320_721 |
| PubMedSearch : Koellner_2002_J.Mol.Biol_320_721 |
| PubMedID: 12095250 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs - Bartolucci_2001_Proteins_42_182 |
| Author(s) : Bartolucci C , Perola E , Pilger C , Fels G , Lamba D |
| Ref : Proteins , 42 :182 , 2001 |
| Abstract : Bartolucci_2001_Proteins_42_182 |
| ESTHER : Bartolucci_2001_Proteins_42_182 |
| PubMedSearch : Bartolucci_2001_Proteins_42_182 |
| PubMedID: 11119642 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A structure-based design approach to the development of novel, reversible AChE inhibitors - Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| Author(s) : Doucet-Personeni C , Bentley PD , Fletcher RJ , Kinkaid A , Kryger G , Pirard B , Taylor A , Taylor R , Taylor J , Viner R , Silman I , Sussman JL , Greenblatt HM , Lewis T |
| Ref : Journal of Medicinal Chemistry , 44 :3203 , 2001 |
| Abstract : Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| ESTHER : Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| PubMedSearch : Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| PubMedID: 11563919 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Specific chemical and structural damage to proteins produced by synchrotron radiation - Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| Author(s) : Weik M , Ravelli RB , Kryger G , McSweeney S , Raves ML , Harel M , Gros P , Silman I , Kroon J , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 97 :623 , 2000 |
| Abstract : Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| ESTHER : Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| PubMedSearch : Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| PubMedID: 10639129 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Back Door Opening Implied by the Crystal Structure of a Carbamoylated Acetylcholinesterase - Bartolucci_1999_Biochemistry_38_5714 |
| Author(s) : Bartolucci C , Perola E , Cellai L , Brufani M , Lamba D |
| Ref : Biochemistry , 38 :5714 , 1999 |
| Abstract : Bartolucci_1999_Biochemistry_38_5714 |
| ESTHER : Bartolucci_1999_Biochemistry_38_5714 |
| PubMedSearch : Bartolucci_1999_Biochemistry_38_5714 |
| PubMedID: 10231521 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution - Greenblatt_1999_FEBS.Lett_463_321 |
| Author(s) : Greenblatt HM , Kryger G , Lewis T , Silman I , Sussman JL |
| Ref : FEBS Letters , 463 :321 , 1999 |
| Abstract : Greenblatt_1999_FEBS.Lett_463_321 |
| ESTHER : Greenblatt_1999_FEBS.Lett_463_321 |
| PubMedSearch : Greenblatt_1999_FEBS.Lett_463_321 |
| PubMedID: 10606746 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs - Kryger_1999_Structure_7_297 |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : Structure , 7 :297 , 1999 |
| Abstract : Kryger_1999_Structure_7_297 |
| ESTHER : Kryger_1999_Structure_7_297 |
| PubMedSearch : Kryger_1999_Structure_7_297 |
| PubMedID: 10368299 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032 |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : Biochemistry , 38 :7032 , 1999 |
| Abstract : Millard_1999_Biochemistry_38_7032 |
| ESTHER : Millard_1999_Biochemistry_38_7032 |
| PubMedSearch : Millard_1999_Biochemistry_38_7032 |
| PubMedID: 10353814 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad - Millard_1999_J.Am.Chem.Soc_121_9883 |
| Author(s) : Millard CB , Koellner G , Ordentlich A , Shafferman A , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 121 :9883 , 1999 |
| Abstract : Millard_1999_J.Am.Chem.Soc_121_9883 |
| ESTHER : Millard_1999_J.Am.Chem.Soc_121_9883 |
| PubMedSearch : Millard_1999_J.Am.Chem.Soc_121_9883 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43 |
| Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL |
| Ref : Chemico-Biological Interactions , 119-120 :43 , 1999 |
| Abstract : Silman_1999_Chem.Biol.Interact_119-120_43 |
| ESTHER : Silman_1999_Chem.Biol.Interact_119-120_43 |
| PubMedSearch : Silman_1999_Chem.Biol.Interact_119-120_43 |
| PubMedID: 10421437 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : Static laue diffraction studies on acetylcholinesterase - Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| Author(s) : Ravelli RB , Raves ML , Ren Z , Bourgeois D , Roth M , Kroon J , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 54 :1359 , 1998 |
| Abstract : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| ESTHER : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| PubMedSearch : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| PubMedID: 10089512 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A - Raves_1997_Nat.Struct.Biol_4_57 |
| Author(s) : Raves ML , Harel M , Pang YP , Silman I , Kozikowski AP , Sussman JL |
| Ref : Nat Struct Biol , 4 :57 , 1997 |
| Abstract : Raves_1997_Nat.Struct.Biol_4_57 |
| ESTHER : Raves_1997_Nat.Struct.Biol_4_57 |
| PubMedSearch : Raves_1997_Nat.Struct.Biol_4_57 |
| PubMedID: 8989325 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. - |
| Author(s) : Harel M , Quinn DM , Nair HK , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 118 :2340 , 1996 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target - Harel_1995_Structure_3_1355 |
| Author(s) : Harel M , Kleywegt GJ , Ravelli RB , Silman I , Sussman JL |
| Ref : Structure , 3 :1355 , 1995 |
| Abstract : Harel_1995_Structure_3_1355 |
| ESTHER : Harel_1995_Structure_3_1355 |
| PubMedSearch : Harel_1995_Structure_3_1355 |
| PubMedID: 8747462 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials - Kreimer_1994_Biochemistry_33_14407 |
| Author(s) : Kreimer DI , Dolginova EA , Raves ML , Sussman JL , Silman I , Weiner L |
| Ref : Biochemistry , 33 :14407 , 1994 |
| Abstract : Kreimer_1994_Biochemistry_33_14407 |
| ESTHER : Kreimer_1994_Biochemistry_33_14407 |
| PubMedSearch : Kreimer_1994_Biochemistry_33_14407 |
| PubMedID: 7981200 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase - Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| Author(s) : Harel M , Schalk I , Ehret-Sabatier L , Bouet F , Goeldner M , Hirth C , Axelsen PH , Silman I , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :9031 , 1993 |
| Abstract : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| ESTHER : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| PubMedSearch : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| PubMedID: 8415649 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein - Sussman_1991_Science_253_872 |
| Author(s) : Sussman JL , Harel M , Frolow F , Oefner C , Goldman A , Toker L , Silman I |
| Ref : Science , 253 :872 , 1991 |
| Abstract : Sussman_1991_Science_253_872 |
| ESTHER : Sussman_1991_Science_253_872 |
| PubMedSearch : Sussman_1991_Science_253_872 |
| PubMedID: 1678899 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence - Schumacher_1986_Nature_319_407 |
| Author(s) : Schumacher M , Camp S , Maulet Y , Newton M , MacPhee-Quigley K , Taylor SS , Friedmann T , Taylor P |
| Ref : Nature , 319 :407 , 1986 |
| Abstract : Schumacher_1986_Nature_319_407 |
| ESTHER : Schumacher_1986_Nature_319_407 |
| PubMedSearch : Schumacher_1986_Nature_319_407 |
| PubMedID: 3753747 |
| Gene_locus related to this paper: torca-ACHE |