ompol-OphP
Omphalotus olearius (Jack o'lantern) macrocyclase OphP prolyl oligopeptidase
Comment
N-methylated peptide macrocycle omphalotin A (nematicidal cyclododecapeptide). A methyltransferase OphMA that catalyzes the automethylation of its C-terminus, which is then released and cyclized by the protease OphP
Relationship
Molecular evidence
Sequence
Peptide
MSFPGWGPYP PVERDETSAI TYSSKLHGSV TVRDPYSQLE VPFEDSEETK AFVHSQRKFA RTYLDENPDR EAWLETLKKS WNYRRFSALK PESDGHYYFE YNDGLQSQLS LYRVRMGEED TVLTESGPGG ELFFNPNLLS LDGNAALTGF VMSPCGNYWA YGVSEHGSDW MSIYVRKTSS PHLPSQERGK DPGRMNDKIR HVRFFIVSWT SDSKGFFYSR YPPEDDEGKG NAPAMNCMVY YHRIGEDQES DVLVHEDPEH PFWISSVQLT PSGRYILFAA SRDASHTQLV KIADLHENDI GTNMKWKNLH DPWEARFTIV GDEGSKIYFM TNLKAKNYKV ATFDANHPDE GLTTLIAEDP NAFLVSASIH AQDKLLLVYL RNASHEIHIR DLTTGKPLGR IFEDLLGQFM VSGRRQDNDI FVLFSSFLSP GTVYRYTFGE EKGYRSLFRA ISIPGLNLDD FMTESVFYPS KDGTSVHMFI TRPKDVLLDG TSPVLQYGYG GFSLAMLPTF SLSTLLFCKI YRAIYAIPNI RGGSEYGESW HREGMLDKKQ NVFDDFNAAT EWLIANKYAS KDRIAIRGGS NGGVLTTACA NQAPGLYRCV ITIEGIIDML RFPKFTFGAS WRSEYGDPED PEDFDFIFKY SPYHNIPPPG DTVMPAMLFF TAAYDDRVSP LHTFKHVAAL QHNFPKGPNP CLMRIDLNSG HFAGKSTQEM LEETADEYSF IGKSMGLTMQ TQGSVDSSRW SCVTV
References
| Title : Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides - Matabaro_2022_bioRxiv__ |
| Author(s) : Matabaro E , Song H , Sonderegger L , Gherlone F , Giltrap A , Liver S , Gossert A , Kunzler M , Naismith JH |
| Ref : Biorxiv , : , 2022 |
| Abstract : Matabaro_2022_bioRxiv__ |
| ESTHER : Matabaro_2022_bioRxiv__ |
| PubMedSearch : Matabaro_2022_bioRxiv__ |
| PubMedID: |
| Gene_locus related to this paper: ompol-OphP |
| Title : Enzyme-mediated backbone N-methylation in ribosomally encoded peptides - Matabaro_2021_Methods.Enzymol_656_429 |
| Author(s) : Matabaro E , Song H , Chepkirui C , Kaspar H , Witte L , Naismith JH , Freeman MF , Kunzler M |
| Ref : Methods Enzymol , 656 :429 , 2021 |
| Abstract : Matabaro_2021_Methods.Enzymol_656_429 |
| ESTHER : Matabaro_2021_Methods.Enzymol_656_429 |
| PubMedSearch : Matabaro_2021_Methods.Enzymol_656_429 |
| PubMedID: 34325794 |
| Gene_locus related to this paper: ompol-OphP |
| Title : Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A - Matabaro_2021_Sci.Rep_11_3541 |
| Author(s) : Matabaro E , Kaspar H , Dahlin P , Bader DLV , Murar CE , Staubli F , Field CM , Bode JW , Kunzler M |
| Ref : Sci Rep , 11 :3541 , 2021 |
| Abstract : Matabaro_2021_Sci.Rep_11_3541 |
| ESTHER : Matabaro_2021_Sci.Rep_11_3541 |
| PubMedSearch : Matabaro_2021_Sci.Rep_11_3541 |
| PubMedID: 33574430 |
| Gene_locus related to this paper: ompol-OphP |
| Title : A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin - Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| Author(s) : Ramm S , Krawczyk B , Muhlenweg A , Poch A , Mosker E , Sussmuth RD |
| Ref : Angew Chem Int Ed Engl , 56 :9994 , 2017 |
| Abstract : Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| ESTHER : Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| PubMedSearch : Ramm_2017_Angew.Chem.Int.Ed.Engl_56_9994 |
| PubMedID: 28715095 |
| Gene_locus related to this paper: ompol-OphP |