Mycobacterium tuberculosis, Mycobacterium bovis, polyketide synthase Thioesterase domain (PKS13 Rv3800c MT3907)
There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
VPVFVFHPAG GSTVVYEPLL GRLPADTPMY GFERVEGSIE ERAQQYVPKL IEMQGDGPYV LVGWSLGGVL AYACAIGLRR LGKDVRFVGL IDAVRAGEEI PQTKEEIRKR WDRYAAFAEK TFNVTIPAIP YEQLEELDDE GQVRFVLDAV SQSGVQIPAG IIEHQRTSYL DNRAIDTAQI QPYDGHVTLY MADRYHDDAI MFEPRYAVRQ PDGGWGEYVS DLEVVPIGGE HIQAIDEPII AKVGEHMSRA LGQIEADRTS EVGKQ
Title : Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity - Green_2023_J.Med.Chem__ |
Author(s) : Green SR , Wilson C , Eadsforth TC , Punekar AS , Tamaki FK , Wood G , Caldwell N , Forte B , Norcross NR , Kiczun M , Post JM , Lopez-Roman EM , Engelhart CA , Lukac I , Zuccotto F , Epemolu O , Boshoff HIM , Schnappinger D , Walpole C , Gilbert IH , Read KD , Wyatt PG , Baragana B |
Ref : Journal of Medicinal Chemistry , : , 2023 |
Abstract : Green_2023_J.Med.Chem__ |
ESTHER : Green_2023_J.Med.Chem__ |
PubMedSearch : Green_2023_J.Med.Chem__ |
PubMedID: 37948640 |
Gene_locus related to this paper: myctu-PKS13 |
Title : An integrated computational approach towards novel drugs discovery against polyketide synthase 13 thioesterase domain of Mycobacterium tuberculosis - Altharawi_2023_Sci.Rep_13_7014 |
Author(s) : Altharawi A , Alossaimi MA , Alanazi MM , Alqahatani SM , Tahir Ul Qamar M |
Ref : Sci Rep , 13 :7014 , 2023 |
Abstract : Altharawi_2023_Sci.Rep_13_7014 |
ESTHER : Altharawi_2023_Sci.Rep_13_7014 |
PubMedSearch : Altharawi_2023_Sci.Rep_13_7014 |
PubMedID: 37117557 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment - Zhang_2022_J.Med.Chem_65_13240 |
Author(s) : Zhang W , Lun S , Wang SS , Cai YP , Yang F , Tang J , Bishai WR , Yu LF |
Ref : Journal of Medicinal Chemistry , 65 :13240 , 2022 |
Abstract : Zhang_2022_J.Med.Chem_65_13240 |
ESTHER : Zhang_2022_J.Med.Chem_65_13240 |
PubMedSearch : Zhang_2022_J.Med.Chem_65_13240 |
PubMedID: 36174223 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13\; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target - Wilson_2022_J.Med.Chem_65_409 |
Author(s) : Wilson C , Ray P , Zuccotto F , Hernandez J , Aggarwal A , Mackenzie C , Caldwell N , Taylor M , Huggett M , Mathieson M , Murugesan D , Smith A , Davis S , Cocco M , Parai MK , Acharya A , Tamaki F , Scullion P , Epemolu O , Riley J , Stojanovski L , Lopez-Roman EM , Torres-Gomez PA , Toledo AM , Guijarro-Lopez L , Camino I , Engelhart CA , Schnappinger D , Massoudi LM , Lenaerts A , Robertson GT , Walpole C , Matthews D , Floyd D , Sacchettini JC , Read KD , Encinas L , Bates RH , Green SR , Wyatt PG |
Ref : Journal of Medicinal Chemistry , 65 :409 , 2022 |
Abstract : Wilson_2022_J.Med.Chem_65_409 |
ESTHER : Wilson_2022_J.Med.Chem_65_409 |
PubMedSearch : Wilson_2022_J.Med.Chem_65_409 |
PubMedID: 34910486 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules - Zhang_2021_Eur.J.Med.Chem_213_113202 |
Author(s) : Zhang W , Liu LL , Lun S , Wang SS , Xiao S , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF |
Ref : Eur Journal of Medicinal Chemistry , 213 :113202 , 2021 |
Abstract : Zhang_2021_Eur.J.Med.Chem_213_113202 |
ESTHER : Zhang_2021_Eur.J.Med.Chem_213_113202 |
PubMedSearch : Zhang_2021_Eur.J.Med.Chem_213_113202 |
PubMedID: 33516983 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II - Zhang_2019_J.Med.Chem_62_3575 |
Author(s) : Zhang W , Lun S , Liu LL , Xiao S , Duan G , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF |
Ref : Journal of Medicinal Chemistry , 62 :3575 , 2019 |
Abstract : Zhang_2019_J.Med.Chem_62_3575 |
ESTHER : Zhang_2019_J.Med.Chem_62_3575 |
PubMedSearch : Zhang_2019_J.Med.Chem_62_3575 |
PubMedID: 30875203 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis - Zhang_2018_J.Med.Chem_61_791 |
Author(s) : Zhang W , Lun S , Wang SH , Jiang XW , Yang F , Tang J , Manson AL , Earl AM , Gunosewoyo H , Bishai WR , Yu LF |
Ref : Journal of Medicinal Chemistry , 61 :791 , 2018 |
Abstract : Zhang_2018_J.Med.Chem_61_791 |
ESTHER : Zhang_2018_J.Med.Chem_61_791 |
PubMedSearch : Zhang_2018_J.Med.Chem_61_791 |
PubMedID: 29328655 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis - Yu_2018_PeerJ_6_e4728 |
Author(s) : Yu M , Dou C , Gu Y , Cheng W |
Ref : PeerJ , 6 :e4728 , 2018 |
Abstract : Yu_2018_PeerJ_6_e4728 |
ESTHER : Yu_2018_PeerJ_6_e4728 |
PubMedSearch : Yu_2018_PeerJ_6_e4728 |
PubMedID: 29761048 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases - Goins_2018_Biochemistry_57_2383 |
Author(s) : Goins CM , Sudasinghe TD , Liu X , Wang Y , O'Doherty GA , Ronning DR |
Ref : Biochemistry , 57 :2383 , 2018 |
Abstract : Goins_2018_Biochemistry_57_2383 |
ESTHER : Goins_2018_Biochemistry_57_2383 |
PubMedSearch : Goins_2018_Biochemistry_57_2383 |
PubMedID: 29601187 |
Gene_locus related to this paper: myctu-a85c , myctu-PKS13 , myctu-Rv3802c |
Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249 |
Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC |
Ref : Cell , 170 :249 , 2017 |
Abstract : Aggarwal_2017_Cell_170_249 |
ESTHER : Aggarwal_2017_Cell_170_249 |
PubMedSearch : Aggarwal_2017_Cell_170_249 |
PubMedID: 28669536 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis - Thanna_2016_Org.Biomol.Chem_14_6119 |
Author(s) : Thanna S , Knudson SE , Grzegorzewicz A , Kapil S , Goins CM , Ronning DR , Jackson M , Slayden RA , Sucheck SJ |
Ref : Org Biomol Chem , 14 :6119 , 2016 |
Abstract : Thanna_2016_Org.Biomol.Chem_14_6119 |
ESTHER : Thanna_2016_Org.Biomol.Chem_14_6119 |
PubMedSearch : Thanna_2016_Org.Biomol.Chem_14_6119 |
PubMedID: 27251120 |
Gene_locus related to this paper: myctu-PKS13 |
Title : The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria - Gavalda_2014_Chem.Biol_21_1660 |
Author(s) : Gavalda S , Bardou F , Laval F , Bon C , Malaga W , Chalut C , Guilhot C , Mourey L , Daffe M , Quemard A |
Ref : Chemical Biology , 21 :1660 , 2014 |
Abstract : Gavalda_2014_Chem.Biol_21_1660 |
ESTHER : Gavalda_2014_Chem.Biol_21_1660 |
PubMedSearch : Gavalda_2014_Chem.Biol_21_1660 |
PubMedID: 25467124 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis - Wilson_2013_Nat.Chem.Biol_9_499 |
Author(s) : Wilson R , Kumar P , Parashar V , Vilcheze C , Veyron-Churlet R , Freundlich JS , Barnes SW , Walker JR , Szymonifka MJ , Marchiano E , Shenai S , Colangeli R , Jacobs WR, Jr. , Neiditch MB , Kremer L , Alland D |
Ref : Nat Chemical Biology , 9 :499 , 2013 |
Abstract : Wilson_2013_Nat.Chem.Biol_9_499 |
ESTHER : Wilson_2013_Nat.Chem.Biol_9_499 |
PubMedSearch : Wilson_2013_Nat.Chem.Biol_9_499 |
PubMedID: 23770708 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13 - Bergeret_2012_J.Biol.Chem_287_33675 |
Author(s) : Bergeret F , Gavalda S , Chalut C , Malaga W , Quemard A , Pedelacq JD , Daffe M , Guilhot C , Mourey L , Bon C |
Ref : Journal of Biological Chemistry , 287 :33675 , 2012 |
Abstract : Bergeret_2012_J.Biol.Chem_287_33675 |
ESTHER : Bergeret_2012_J.Biol.Chem_287_33675 |
PubMedSearch : Bergeret_2012_J.Biol.Chem_287_33675 |
PubMedID: 22825853 |
Gene_locus related to this paper: myctu-PKS13 |
Title : Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry - Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627 |
Author(s) : Kelkar DS , Kumar D , Kumar P , Balakrishnan L , Muthusamy B , Yadav AK , Shrivastava P , Marimuthu A , Anand S , Sundaram H , Kingsbury R , Harsha HC , Nair B , Prasad TS , Chauhan DS , Katoch K , Katoch VM , Chaerkady R , Ramachandran S , Dash D , Pandey A |
Ref : Mol Cell Proteomics , 10 :M111 011627 , 2011 |
Abstract : Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627 |
ESTHER : Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627 |
PubMedSearch : Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627 |
PubMedID: 21969609 |
Gene_locus related to this paper: myctu-ephA , myctu-ephB , myctu-ephd , myctu-linb , myctu-MBTB , myctu-PKS13 , myctu-Rv1833c , myctu-RV2296 , myctu-RV2695 , myctu-RV2765 |
Title : The Pks13\/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis - Gavalda_2009_J.Biol.Chem_284_19255 |
Author(s) : Gavalda S , Leger M , van der Rest B , Stella A , Bardou F , Montrozier H , Chalut C , Burlet-Schiltz O , Marrakchi H , Daffe M , Quemard A |
Ref : Journal of Biological Chemistry , 284 :19255 , 2009 |
Abstract : Gavalda_2009_J.Biol.Chem_284_19255 |
ESTHER : Gavalda_2009_J.Biol.Chem_284_19255 |
PubMedSearch : Gavalda_2009_J.Biol.Chem_284_19255 |
PubMedID: 19436070 |
Gene_locus related to this paper: myctu-PKS13 |
Title : The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis - Leger_2009_Chem.Biol_16_510 |
Author(s) : Leger M , Gavalda S , Guillet V , van der Rest B , Slama N , Montrozier H , Mourey L , Quemard A , Daffe M , Marrakchi H |
Ref : Chemical Biology , 16 :510 , 2009 |
Abstract : Leger_2009_Chem.Biol_16_510 |
ESTHER : Leger_2009_Chem.Biol_16_510 |
PubMedSearch : Leger_2009_Chem.Biol_16_510 |
PubMedID: 19477415 |
Gene_locus related to this paper: myctu-PKS13 |
Title : The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria - Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511 |
Author(s) : Chalut C , Botella L , de Sousa-D'Auria C , Houssin C , Guilhot C |
Ref : Proc Natl Acad Sci U S A , 103 :8511 , 2006 |
Abstract : Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511 |
ESTHER : Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511 |
PubMedSearch : Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511 |
PubMedID: 16709676 |
Gene_locus related to this paper: myctu-PKS13 |