Mus musculus mRNA for hormone sensitive lipase
Q9CTW2 Kawai differs only 1aa from P54310 || (from Uniprot) Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
MDLRTMTQSL VTLAEDNMAF FSSQGPGETA RRLSNVFAGV REQALGLEPT LGQLLGVAHH FDLDTETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRKSI FFRASHNLAE LEAYLAALTQ LRAMAYYAQR LLTINRPGVL FFEGDEGLTA DFLQEYVTLH KGCFYGRCLG FQFTPAIRPF LQTLSIGLVS FGEHYKRNET GLSVTASSLF TGGRFAIDPE LRGAEFERII QNLDVHFWKA FWNITEIEVL SSLANMASTT VRVSRLLSLP PEAFEMPLTS DPRLTVTISP PLAHTGPAPV LARLISYDLR EGQDSKVLNS LAKSEGPRLD VRPRPHQAPR SRALVVHIHG GGFVAQTSKS HEPYLKNWAQ ELGVPIFSID YSLAPEAPFP RALEECFFAY CWAVKHCDLL GSTGERICLA GDSAGGNLCI TVSLRAAAYG VRVPDGIMAA YPVTTLQSSA SPSRLLSLMD PLLPLSVLSK CVSAYSGTEA EDHFDSDQKA LGVMGLVQRD TSLFLRDLRL GASSWLNSFP ELSGRKPQKT TSPTAESVRP TESMRRSVSE AALAQPEGLL GTDTLKKLTI KDLSNSEPSD SPEMSQSMET LGPSTPSDVN FFLRPGNSQE EAEAKDEVRP MDGVPRVRAA FPEGFHPRRS SQGVLHMPLY TSPIVKNPFM SPLLAPDSML KTLPPVHLVA CALDPMLDDS VMFARRLRDL GQPVTLKVVE DLPHGFLSLA ALCRETRQAT EFCVQRIRLI LTPPAAPLN
Title : Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory - Skoug_2024_J.Neurochem__ |
Author(s) : Skoug C , Rogova O , Spegel P , Holm C , Duarte JMN |
Ref : Journal of Neurochemistry , : , 2024 |
Abstract : Skoug_2024_J.Neurochem__ |
ESTHER : Skoug_2024_J.Neurochem__ |
PubMedSearch : Skoug_2024_J.Neurochem__ |
PubMedID: 38317494 |
Gene_locus related to this paper: mouse-hslip |
Title : An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis - Zhang_2019_Cells_8_395 |
Author(s) : Zhang X , Zhang CC , Yang H , Soni KG , Wang SP , Mitchell GA , Wu JW |
Ref : Cells , 8 :395 , 2019 |
Abstract : Zhang_2019_Cells_8_395 |
ESTHER : Zhang_2019_Cells_8_395 |
PubMedSearch : Zhang_2019_Cells_8_395 |
PubMedID: 31035700 |
Gene_locus related to this paper: mouse-hslip |
Title : Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice - Xu_2018_BMC.Cancer_18_797 |
Author(s) : Xu M , Chang HH , Jung X , Moro A , Chou CEN , King J , Hines OJ , Sinnett-Smith J , Rozengurt E , Eibl G |
Ref : BMC Cancer , 18 :797 , 2018 |
Abstract : Xu_2018_BMC.Cancer_18_797 |
ESTHER : Xu_2018_BMC.Cancer_18_797 |
PubMedSearch : Xu_2018_BMC.Cancer_18_797 |
PubMedID: 30086728 |
Gene_locus related to this paper: mouse-hslip |
Title : Adipose Tissue Deficiency of Hormone-Sensitive Lipase Causes Fatty Liver in Mice - Xia_2017_PLoS.Genet_13_e1007110 |
Author(s) : Xia B , Cai GH , Yang H , Wang SP , Mitchell GA , Wu JW |
Ref : PLoS Genet , 13 :e1007110 , 2017 |
Abstract : Xia_2017_PLoS.Genet_13_e1007110 |
ESTHER : Xia_2017_PLoS.Genet_13_e1007110 |
PubMedSearch : Xia_2017_PLoS.Genet_13_e1007110 |
PubMedID: 29232702 |
Gene_locus related to this paper: mouse-hslip |
Title : Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice - Wu_2017_PLoS.Genet_13_e1006716 |
Author(s) : Wu JW , Preuss C , Wang SP , Yang H , Ji B , Carter GW , Gladdy R , Andelfinger G , Mitchell GA |
Ref : PLoS Genet , 13 :e1006716 , 2017 |
Abstract : Wu_2017_PLoS.Genet_13_e1006716 |
ESTHER : Wu_2017_PLoS.Genet_13_e1006716 |
PubMedSearch : Wu_2017_PLoS.Genet_13_e1006716 |
PubMedID: 28459858 |
Gene_locus related to this paper: mouse-hslip |
Title : The catalytic function of hormone-sensitive lipase is essential for fertility in male mice - Wang_2014_Endocrinology_155_3047 |
Author(s) : Wang SP , Wu JW , Bourdages H , Lefebvre JF , Casavant S , Leavitt BR , Labuda D , Trasler J , Smith CE , Hermo L , Mitchell GA |
Ref : Endocrinology , 155 :3047 , 2014 |
Abstract : Wang_2014_Endocrinology_155_3047 |
ESTHER : Wang_2014_Endocrinology_155_3047 |
PubMedSearch : Wang_2014_Endocrinology_155_3047 |
PubMedID: 24797631 |
Gene_locus related to this paper: mouse-hslip |
Title : Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass - Girousse_2013_PLoS.Biol_11_e1001485 |
Author(s) : Girousse A , Tavernier G , Valle C , Moro C , Mejhert N , Dinel AL , Houssier M , Roussel B , Besse-Patin A , Combes M , Mir L , Monbrun L , Bezaire V , Prunet-Marcassus B , Waget A , Vila I , Caspar-Bauguil S , Louche K , Marques MA , Mairal A , Renoud ML , Galitzky J , Holm C , Mouisel E , Thalamas C , Viguerie N , Sulpice T , Burcelin R , Arner P , Langin D |
Ref : PLoS Biol , 11 :e1001485 , 2013 |
Abstract : Girousse_2013_PLoS.Biol_11_e1001485 |
ESTHER : Girousse_2013_PLoS.Biol_11_e1001485 |
PubMedSearch : Girousse_2013_PLoS.Biol_11_e1001485 |
PubMedID: 23431266 |
Gene_locus related to this paper: mouse-hslip |
Title : Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice - Obrowsky_2012_Biochim.Biophys.Acta_1821_1406 |
Author(s) : Obrowsky S , Chandak PG , Patankar JV , Pfeifer T , Povoden S , Schreiber R , Haemmerle G , Levak-Frank S , Kratky D |
Ref : Biochimica & Biophysica Acta , 1821 :1406 , 2012 |
Abstract : Obrowsky_2012_Biochim.Biophys.Acta_1821_1406 |
ESTHER : Obrowsky_2012_Biochim.Biophys.Acta_1821_1406 |
PubMedSearch : Obrowsky_2012_Biochim.Biophys.Acta_1821_1406 |
PubMedID: 22842588 |
Gene_locus related to this paper: mouse-hslip |
Title : Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models - Girousse_2012_Int.J.Obes.(Lond)_36_581 |
Author(s) : Girousse A , Langin D |
Ref : Int J Obes (Lond) , 36 :581 , 2012 |
Abstract : Girousse_2012_Int.J.Obes.(Lond)_36_581 |
ESTHER : Girousse_2012_Int.J.Obes.(Lond)_36_581 |
PubMedSearch : Girousse_2012_Int.J.Obes.(Lond)_36_581 |
PubMedID: 21673652 |
Gene_locus related to this paper: mouse-hslip |
Title : Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice - Fernandez_2011_PLoS.One_6_e21603 |
Author(s) : Fernandez C , Schuhmann K , Herzog R , Fielding B , Frayn K , Shevchenko A , James P , Holm C , Strom K |
Ref : PLoS ONE , 6 :e21603 , 2011 |
Abstract : Fernandez_2011_PLoS.One_6_e21603 |
ESTHER : Fernandez_2011_PLoS.One_6_e21603 |
PubMedSearch : Fernandez_2011_PLoS.One_6_e21603 |
PubMedID: 21738729 |
Gene_locus related to this paper: mouse-hslip |
Title : Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice - Pinent_2011_Endocrinology_152_2678 |
Author(s) : Pinent M , Prokesch A , Hackl H , Voshol PJ , Klatzer A , Walenta E , Panzenboeck U , Kenner L , Trajanoski Z , Hoefler G , Bogner-Strauss JG |
Ref : Endocrinology , 152 :2678 , 2011 |
Abstract : Pinent_2011_Endocrinology_152_2678 |
ESTHER : Pinent_2011_Endocrinology_152_2678 |
PubMedSearch : Pinent_2011_Endocrinology_152_2678 |
PubMedID: 21540289 |
Gene_locus related to this paper: mouse-hslip |
Title : Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility - Hermo_2008_Mol.Reprod.Dev_75_565 |
Author(s) : Hermo L , Chung S , Gregory M , Smith CE , Wang SP , El-Alfy M , Cyr DG , Mitchell GA , Trasler J |
Ref : Mol Reprod Dev , 75 :565 , 2008 |
Abstract : Hermo_2008_Mol.Reprod.Dev_75_565 |
ESTHER : Hermo_2008_Mol.Reprod.Dev_75_565 |
PubMedSearch : Hermo_2008_Mol.Reprod.Dev_75_565 |
PubMedID: 17886267 |
Gene_locus related to this paper: mouse-hslip |
Title : Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart - Park_2005_Am.J.Physiol.Endocrinol.Metab_289_E30 |
Author(s) : Park SY , Kim HJ , Wang S , Higashimori T , Dong J , Kim YJ , Cline G , Li H , Prentki M , Shulman GI , Mitchell GA , Kim JK |
Ref : American Journal of Physiology Endocrinol Metab , 289 :E30 , 2005 |
Abstract : Park_2005_Am.J.Physiol.Endocrinol.Metab_289_E30 |
ESTHER : Park_2005_Am.J.Physiol.Endocrinol.Metab_289_E30 |
PubMedSearch : Park_2005_Am.J.Physiol.Endocrinol.Metab_289_E30 |
PubMedID: 15701680 |
Gene_locus related to this paper: mouse-hslip |
Title : Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice - Fortier_2005_J.Lipid.Res_46_1860 |
Author(s) : Fortier M , Soni K , Laurin N , Wang SP , Mauriege P , Jirik FR , Mitchell GA |
Ref : J Lipid Res , 46 :1860 , 2005 |
Abstract : Fortier_2005_J.Lipid.Res_46_1860 |
ESTHER : Fortier_2005_J.Lipid.Res_46_1860 |
PubMedSearch : Fortier_2005_J.Lipid.Res_46_1860 |
PubMedID: 15961788 |
Gene_locus related to this paper: mouse-hslip |
Title : Expression of human hormone-sensitive lipase (HSL) in postmeiotic germ cells confers normal fertility to HSL-deficient mice - Wang_2004_Endocrinology_145_5688 |
Author(s) : Wang SP , Chung S , Soni K , Bourdages H , Hermo L , Trasler J , Mitchell GA |
Ref : Endocrinology , 145 :5688 , 2004 |
Abstract : Wang_2004_Endocrinology_145_5688 |
ESTHER : Wang_2004_Endocrinology_145_5688 |
PubMedSearch : Wang_2004_Endocrinology_145_5688 |
PubMedID: 15345679 |
Gene_locus related to this paper: mouse-hslip |
Title : Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading - Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
Author(s) : Fortier M , Wang SP , Mauriege P , Semache M , Mfuma L , Li H , Levy E , Richard D , Mitchell GA |
Ref : American Journal of Physiology Endocrinol Metab , 287 :E282 , 2004 |
Abstract : Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
ESTHER : Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
PubMedSearch : Fortier_2004_Am.J.Physiol.Endocrinol.Metab_287_E282 |
PubMedID: 15271647 |
Gene_locus related to this paper: mouse-hslip |
Title : Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1 - Peyot_2004_Diabetes_53_1733 |
Author(s) : Peyot ML , Nolan CJ , Soni K , Joly E , Lussier R , Corkey BE , Wang SP , Mitchell GA , Prentki M |
Ref : Diabetes , 53 :1733 , 2004 |
Abstract : Peyot_2004_Diabetes_53_1733 |
ESTHER : Peyot_2004_Diabetes_53_1733 |
PubMedSearch : Peyot_2004_Diabetes_53_1733 |
PubMedID: 15220197 |
Gene_locus related to this paper: mouse-hslip |
Title : Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice - Voshol_2003_Endocrinology_144_3456 |
Author(s) : Voshol PJ , Haemmerle G , Ouwens DM , Zimmermann R , Zechner R , Teusink B , Maassen JA , Havekes LM , Romijn JA |
Ref : Endocrinology , 144 :3456 , 2003 |
Abstract : Voshol_2003_Endocrinology_144_3456 |
ESTHER : Voshol_2003_Endocrinology_144_3456 |
PubMedSearch : Voshol_2003_Endocrinology_144_3456 |
PubMedID: 12865325 |
Gene_locus related to this paper: mouse-hslip |
Title : Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation - Li_2002_Endocrinology_143_3333 |
Author(s) : Li H , Brochu M , Wang SP , Rochdi L , Cote M , Mitchell G , Gallo-Payet N |
Ref : Endocrinology , 143 :3333 , 2002 |
Abstract : Li_2002_Endocrinology_143_3333 |
ESTHER : Li_2002_Endocrinology_143_3333 |
PubMedSearch : Li_2002_Endocrinology_143_3333 |
PubMedID: 12193545 |
Gene_locus related to this paper: mouse-hslip |
Title : Infertility and testicular defects in hormone-sensitive lipase-deficient mice - Chung_2001_Endocrinology_142_4272 |
Author(s) : Chung S , Wang SP , Pan L , Mitchell G , Trasler J , Hermo L |
Ref : Endocrinology , 142 :4272 , 2001 |
Abstract : Chung_2001_Endocrinology_142_4272 |
ESTHER : Chung_2001_Endocrinology_142_4272 |
PubMedSearch : Chung_2001_Endocrinology_142_4272 |
PubMedID: 11564684 |
Gene_locus related to this paper: mouse-hslip |
Title : A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice - Roduit_2001_Diabetes_50_1970 |
Author(s) : Roduit R , Masiello P , Wang SP , Li H , Mitchell GA , Prentki M |
Ref : Diabetes , 50 :1970 , 2001 |
Abstract : Roduit_2001_Diabetes_50_1970 |
ESTHER : Roduit_2001_Diabetes_50_1970 |
PubMedSearch : Roduit_2001_Diabetes_50_1970 |
PubMedID: 11522661 |
Gene_locus related to this paper: mouse-hslip |
Title : The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice - Wang_2001_Obes.Res_9_119 |
Author(s) : Wang SP , Laurin N , Himms-Hagen J , Rudnicki MA , Levy E , Robert MF , Pan L , Oligny L , Mitchell GA |
Ref : Obes Res , 9 :119 , 2001 |
Abstract : Wang_2001_Obes.Res_9_119 |
ESTHER : Wang_2001_Obes.Res_9_119 |
PubMedSearch : Wang_2001_Obes.Res_9_119 |
PubMedID: 11316346 |
Gene_locus related to this paper: mouse-hslip |
Title : Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes - Carninci_2000_Genome.Res_10_1617 |
Author(s) : Carninci P , Shibata Y , Hayatsu N , Sugahara Y , Shibata K , Itoh M , Konno H , Okazaki Y , Muramatsu M , Hayashizaki Y |
Ref : Genome Res , 10 :1617 , 2000 |
Abstract : Carninci_2000_Genome.Res_10_1617 |
ESTHER : Carninci_2000_Genome.Res_10_1617 |
PubMedSearch : Carninci_2000_Genome.Res_10_1617 |
PubMedID: 11042159 |
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-hyes , mouse-lipli , mouse-LIPN , mouse-pafa , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC |
Title : RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer - Shibata_2000_Genome.Res_10_1757 |
Author(s) : Shibata K , Itoh M , Aizawa K , Nagaoka S , Sasaki N , Carninci P , Konno H , Akiyama J , Nishi K , Kitsunai T , Tashiro H , Sumi N , Ishii Y , Nakamura S , Hazama M , Nishine T , Harada A , Yamamoto R , Matsumoto H , Sakaguchi S , Ikegami T , Kashiwagi K , Fujiwake S , Inoue K , Togawa Y |
Ref : Genome Res , 10 :1757 , 2000 |
Abstract : Shibata_2000_Genome.Res_10_1757 |
ESTHER : Shibata_2000_Genome.Res_10_1757 |
PubMedSearch : Shibata_2000_Genome.Res_10_1757 |
PubMedID: 11076861 |
Gene_locus related to this paper: mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 |
Title : Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity - Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787 |
Author(s) : Osuga J , Ishibashi S , Oka T , Yagyu H , Tozawa R , Fujimoto A , Shionoiri F , Yahagi N , Kraemer FB , Tsutsumi O , Yamada N |
Ref : Proc Natl Acad Sci U S A , 97 :787 , 2000 |
Abstract : Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787 |
ESTHER : Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787 |
PubMedSearch : Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787 |
PubMedID: 10639158 |
Gene_locus related to this paper: human-LIPE , mouse-hslip |
Title : High-efficiency full-length cDNA cloning - |
Author(s) : Carninci P , Hayashizaki Y |
Ref : Methods Enzymol , 303 :19 , 1999 |
PubMedID: 10349636 |
Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC |
Title : Hormone-sensitive lipase (Lipe): sequence analysis of the 129Sv mouse Lipe gene - Sztrolovics_1997_Mamm.Genome_8_86 |
Author(s) : Sztrolovics R , Wang SP , Lapierre P , Chen HS , Robert MF , Mitchell GA |
Ref : Mamm Genome , 8 :86 , 1997 |
Abstract : Sztrolovics_1997_Mamm.Genome_8_86 |
ESTHER : Sztrolovics_1997_Mamm.Genome_8_86 |
PubMedSearch : Sztrolovics_1997_Mamm.Genome_8_86 |
PubMedID: 9060404 |
Gene_locus related to this paper: mouse-hslip |
Title : Isolation and characterization of the gene for mouse hormone-sensitive lipase - Li_1994_Genomics_24_259 |
Author(s) : Li Z , Sumida M , Birchbauer A , Schotz MC , Reue K |
Ref : Genomics , 24 :259 , 1994 |
Abstract : Li_1994_Genomics_24_259 |
ESTHER : Li_1994_Genomics_24_259 |
PubMedSearch : Li_1994_Genomics_24_259 |
PubMedID: 7698747 |
Gene_locus related to this paper: mouse-hslip |