Homo sapiens (Human) serine Retinoid-inducible serine carboxypeptidase RISC SCP1 (EC 3.4.16.-)
Homo sapiens (Human) dc39 Trembl Q9H2J9 mstp034 Q9H3F0 Serine carboxypeptidase 1 old human-HSCP1. Kollmann et al. (2009) showed that the 55-kD mouse Scpep1 precursor protein was processed into a 35-kD N-terminal fragment and an 18-kD C-terminal fragment. Processing was mediated by a lysosomal serine proteinase and took place in the endosomal-lysosomal compartment. All 5 putative N-glycosylation sites of Scpep1 were N-glycosylated in mouse embryonic fibroblasts. Lee et al. (2009) showed that Scpep1 expression promoted growth and migration of mouse or rat smooth muscle cells (SMCs). Mutation analysis revealed that the stimulatory effects of Scpep1 on SMC growth and migration required the Scpep1 catalytic triad, but not cleavage of Scpep1. Immunohistochemical analysis of injured mouse and rat carotid arteries demonstrated increased Scpep1 expression in vessel walls where modulated SMCs were proliferative and migratory. By analyzing cultured mouse aortic vascular SMCs (AVSMCs), Pan et al. (2014) showed that Scpep1 had carboxypeptidase activity towards ET1 (EDN1), complementing the serine carboxypeptidase activity of CathA (CTSA). Analysis with purified recombinant protein confirmed that Scpep1 cleaved the C-terminal trp residue from ET1. || also named MSTP034 AF113214
MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY MFWWLYYATN SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP RKTTWLQAAS LLFVDNPVGT GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF SCHKEFQTVP FYIFSESYGG KMAAGIGLEL YKAIQRGTIK CNFAGVALGD SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA VNKGLYREAT ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI SIVDELLEAG INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK ALYSDPKSLE TSAFVKSYKN LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ QE
| Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr. |
| Ref : Journal of the American Chemical Society , 136 :2659 , 2014 |
| Abstract : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| ESTHER : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| PubMedSearch : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| PubMedID: 24447064 |
| Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda |
| Title : Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 - Pan_2014_PLoS.Genet_10_e1004146 |
| Author(s) : Pan X , Grigoryeva L , Seyrantepe V , Peng J , Kollmann K , Tremblay J , Lavoie JL , Hinek A , Lubke T , Pshezhetsky AV |
| Ref : PLoS Genet , 10 :e1004146 , 2014 |
| Abstract : Pan_2014_PLoS.Genet_10_e1004146 |
| ESTHER : Pan_2014_PLoS.Genet_10_e1004146 |
| PubMedSearch : Pan_2014_PLoS.Genet_10_e1004146 |
| PubMedID: 24586188 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1 - Kollmann_2009_Febs.j_276_1356 |
| Author(s) : Kollmann K , Damme M , Deuschl F , Kahle J , D'Hooge R , Lullmann-Rauch R , Lubke T |
| Ref : Febs J , 276 :1356 , 2009 |
| Abstract : Kollmann_2009_Febs.j_276_1356 |
| ESTHER : Kollmann_2009_Febs.j_276_1356 |
| PubMedSearch : Kollmann_2009_Febs.j_276_1356 |
| PubMedID: 19187242 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells - Lee_2009_Circ.Res_105_271 |
| Author(s) : Lee TH , Chen J , Miano JM |
| Ref : Circulation Research , 105 :271 , 2009 |
| Abstract : Lee_2009_Circ.Res_105_271 |
| ESTHER : Lee_2009_Circ.Res_105_271 |
| PubMedSearch : Lee_2009_Circ.Res_105_271 |
| PubMedID: 19574551 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Tissue expression of the novel serine carboxypeptidase Scpep1 - Lee_2006_J.Histochem.Cytochem_54_701 |
| Author(s) : Lee TH , Streb JW , Georger MA , Miano JM |
| Ref : Journal of Histochemistry & Cytochemistry , 54 :701 , 2006 |
| Abstract : Lee_2006_J.Histochem.Cytochem_54_701 |
| ESTHER : Lee_2006_J.Histochem.Cytochem_54_701 |
| PubMedSearch : Lee_2006_J.Histochem.Cytochem_54_701 |
| PubMedID: 16461364 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Signal peptide prediction based on analysis of experimentally verified cleavage sites - Zhang_2004_Protein.Sci_13_2819 |
| Author(s) : Zhang Z , Henzel WJ |
| Ref : Protein Science , 13 :2819 , 2004 |
| Abstract : Zhang_2004_Protein.Sci_13_2819 |
| ESTHER : Zhang_2004_Protein.Sci_13_2819 |
| PubMedSearch : Zhang_2004_Protein.Sci_13_2819 |
| PubMedID: 15340161 |
| Gene_locus related to this paper: human-PLA2G15 , human-SCPEP1 |
| Title : Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry - Zhang_2003_Nat.Biotechnol_21_660 |
| Author(s) : Zhang H , Li XJ , Martin DB , Aebersold R |
| Ref : Nat Biotechnol , 21 :660 , 2003 |
| Abstract : Zhang_2003_Nat.Biotechnol_21_660 |
| ESTHER : Zhang_2003_Nat.Biotechnol_21_660 |
| PubMedSearch : Zhang_2003_Nat.Biotechnol_21_660 |
| PubMedID: 12754519 |
| Gene_locus related to this paper: human-SCPEP1 |
| Title : Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells - Chen_2001_J.Biol.Chem_276_34175 |
| Author(s) : Chen J , Streb JW , Maltby KM , Kitchen CM , Miano JM |
| Ref : Journal of Biological Chemistry , 276 :34175 , 2001 |
| Abstract : Chen_2001_J.Biol.Chem_276_34175 |
| ESTHER : Chen_2001_J.Biol.Chem_276_34175 |
| PubMedSearch : Chen_2001_J.Biol.Chem_276_34175 |
| PubMedID: 11447226 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC , ratno-RISC |