human-LYPLA1
Homo sapiens (Human) lysophospholipase I (LYPLA1) APT1, acyl-protein thioesterase 1 S-depalmitoylase
Comment
Previously characterized as lysophospholipase I, but has several hudred-fold higher activity as a protein thioesterase. Acyl protein thioesterase apt1, which catalyzes depalmitoylation of Galpha proteins and Ras. S-depalmitoylase found both in cytoplasm and mitochondria || . A shorter form exists as a splice variant AF077199 nuc 4679011 pep 4679012 || . Q9UQF9 probable isoform of same gene
Relationship
Molecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MCGNNMSTPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSSHIK YICPHAPVRP VTLNMNVAMP SWFDIIGLSP DSQEDESGIK QAAENIKALI DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFPQGPIGGA NRDISILQCH GDCDPLVPLM FGSLTVEKLK TLVNPANVTF KTYEGMMHSS CQQEMMDVKQ FIDKLLPPID
References
| Title : A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability - Harris_2024_Proteins__ |
| Author(s) : Harris WT, 3rd , Altieri I , Gieck I , Johnson RJ |
| Ref : Proteins , : , 2024 |
| Abstract : Harris_2024_Proteins__ |
| ESTHER : Harris_2024_Proteins__ |
| PubMedSearch : Harris_2024_Proteins__ |
| PubMedID: 38179877 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains - Abrami_2021_Nat.Chem.Biol_17_438 |
| Author(s) : Abrami L , Audagnotto M , Ho S , Marcaida MJ , Mesquita FS , Anwar MU , Sandoz PA , Fonti G , Pojer F , Dal Peraro M , van der Goot FG |
| Ref : Nat Chemical Biology , 17 :438 , 2021 |
| Abstract : Abrami_2021_Nat.Chem.Biol_17_438 |
| ESTHER : Abrami_2021_Nat.Chem.Biol_17_438 |
| PubMedSearch : Abrami_2021_Nat.Chem.Biol_17_438 |
| PubMedID: 33707782 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Inhibition of cell proliferation and migration in nonsmall cell lung cancer cells through the suppression of LYPLA1 - Mohammed_2019_Oncol.Rep_41_973 |
| Author(s) : Mohammed A , Zhang C , Zhang S , Shen Q , Li J , Tang Z , Liu H |
| Ref : Oncol Rep , 41 :973 , 2019 |
| Abstract : Mohammed_2019_Oncol.Rep_41_973 |
| ESTHER : Mohammed_2019_Oncol.Rep_41_973 |
| PubMedSearch : Mohammed_2019_Oncol.Rep_41_973 |
| PubMedID: 30431103 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes - Kathayat_2018_Nat.Commun_9_334 |
| Author(s) : Kathayat RS , Cao Y , Elvira PD , Sandoz PA , Zaballa ME , Springer MZ , Drake LE , Macleod KF , van der Goot FG , Dickinson BC |
| Ref : Nat Commun , 9 :334 , 2018 |
| Abstract : Kathayat_2018_Nat.Commun_9_334 |
| ESTHER : Kathayat_2018_Nat.Commun_9_334 |
| PubMedSearch : Kathayat_2018_Nat.Commun_9_334 |
| PubMedID: 29362370 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011 |
| Abstract : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| ESTHER : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| PubMedSearch : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| PubMedID: 21905186 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Small-molecule inhibition of APT1 affects Ras localization and signaling - Dekker_2010_Nat.Chem.Biol_6_449 |
| Author(s) : Dekker FJ , Rocks O , Vartak N , Menninger S , Hedberg C , Balamurugan R , Wetzel S , Renner S , Gerauer M , Scholermann B , Rusch M , Kramer JW , Rauh D , Coates GW , Brunsveld L , Bastiaens PI , Waldmann H |
| Ref : Nat Chemical Biology , 6 :449 , 2010 |
| Abstract : Dekker_2010_Nat.Chem.Biol_6_449 |
| ESTHER : Dekker_2010_Nat.Chem.Biol_6_449 |
| PubMedSearch : Dekker_2010_Nat.Chem.Biol_6_449 |
| PubMedID: 20418879 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Protein acyl thioesterases (Review) - Zeidman_2009_Mol.Membr.Biol_26_32 |
| Author(s) : Zeidman R , Jackson CS , Magee AI |
| Ref : Mol Membr Biol , 26 :32 , 2009 |
| Abstract : Zeidman_2009_Mol.Membr.Biol_26_32 |
| ESTHER : Zeidman_2009_Mol.Membr.Biol_26_32 |
| PubMedSearch : Zeidman_2009_Mol.Membr.Biol_26_32 |
| PubMedID: 19115143 |
| Gene_locus related to this paper: human-LYPLA1 , human-PPT1 |
| Title : Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A - Devedjiev_2000_Structure_8_1137 |
| Author(s) : Devedjiev Y , Dauter Z , Kuznetsov SR , Jones TL , Derewenda ZS |
| Ref : Structure , 8 :1137 , 2000 |
| Abstract : Devedjiev_2000_Structure_8_1137 |
| ESTHER : Devedjiev_2000_Structure_8_1137 |
| PubMedSearch : Devedjiev_2000_Structure_8_1137 |
| PubMedID: 11080636 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem\/progenitor cells - Zhang_2000_Genome.Res_10_1546 |
| Author(s) : Zhang QH , Ye M , Wu XY , Ren SX , Zhao M , Zhao CJ , Fu G , Shen Y , Fan HY , Lu G , Zhong M , Xu XR , Han ZG , Zhang JW , Tao J , Huang QH , Zhou J , Hu GX , Gu J , Chen SJ , Chen Z |
| Ref : Genome Res , 10 :1546 , 2000 |
| Abstract : Zhang_2000_Genome.Res_10_1546 |
| ESTHER : Zhang_2000_Genome.Res_10_1546 |
| PubMedSearch : Zhang_2000_Genome.Res_10_1546 |
| PubMedID: 11042152 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization - Wang_1999_Biochim.Biophys.Acta_1437_157 |
| Author(s) : Wang A , Yang HC , Friedman P , Johnson CA , Dennis EA |
| Ref : Biochimica & Biophysica Acta , 1437 :157 , 1999 |
| Abstract : Wang_1999_Biochim.Biophys.Acta_1437_157 |
| ESTHER : Wang_1999_Biochim.Biophys.Acta_1437_157 |
| PubMedSearch : Wang_1999_Biochim.Biophys.Acta_1437_157 |
| PubMedID: 10064899 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS) - Duncan_1998_J.Biol.Chem_273_15830 |
| Author(s) : Duncan JA , Gilman AG |
| Ref : Journal of Biological Chemistry , 273 :15830 , 1998 |
| Abstract : Duncan_1998_J.Biol.Chem_273_15830 |
| ESTHER : Duncan_1998_J.Biol.Chem_273_15830 |
| PubMedSearch : Duncan_1998_J.Biol.Chem_273_15830 |
| PubMedID: 9624183 |
| Gene_locus related to this paper: human-LYPLA1 , ratno-lypla1a |