human-ABHD17C

Homo sapiens (Human) Abhydrolase domain-containing protein FAM108C1 Q6PCB6 F108C_HUMAN

Comment

ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015). ABHD17A, 17B, and 17C,are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.<\/A>

Relationship

Family : ABHD17-depalmitoylase

Block : X

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR GAGASAPAPA QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS QRELDAVEVF FSRTARDNRL GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE KNLYADIDAA WQALRTRYGV SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR VAFPDTRKTY CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV EGAGHNDIEL YAQYLERLKQ FISHELPNS

References

Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__
Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF
Ref : Nat Chemical Biology , : , 2021
Abstract : Remsberg_2021_Nat.Chem.Biol__
ESTHER : Remsberg_2021_Nat.Chem.Biol__
PubMedSearch : Remsberg_2021_Nat.Chem.Biol__
PubMedID: 33927411
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization - Tortosa_2017_Neuron_94_809
Author(s) : Tortosa E , Adolfs Y , Fukata M , Pasterkamp RJ , Kapitein LC , Hoogenraad CC
Ref : Neuron , 94 :809 , 2017
Abstract : Tortosa_2017_Neuron_94_809
ESTHER : Tortosa_2017_Neuron_94_809
PubMedSearch : Tortosa_2017_Neuron_94_809
PubMedID: 28521134
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Identification of PSD-95 Depalmitoylating Enzymes - Yokoi_2016_J.Neurosci_36_6431
Author(s) : Yokoi N , Fukata Y , Sekiya A , Murakami T , Kobayashi K , Fukata M
Ref : Journal of Neuroscience , 36 :6431 , 2016
Abstract : Yokoi_2016_J.Neurosci_36_6431
ESTHER : Yokoi_2016_J.Neurosci_36_6431
PubMedSearch : Yokoi_2016_J.Neurosci_36_6431
PubMedID: 27307232
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C , rat-ab17c

Title : ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization - Lin_2015_Elife_4_
Author(s) : Lin DT , Conibear E
Ref : Elife , 4 : , 2015
Abstract : Lin_2015_Elife_4_
ESTHER : Lin_2015_Elife_4_
PubMedSearch : Lin_2015_Elife_4_
PubMedID: 26701913
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Large-scale profiling of protein palmitoylation in mammalian cells - Martin_2009_Nat.Methods_6_135
Author(s) : Martin BR , Cravatt BF
Ref : Nat Methods , 6 :135 , 2009
Abstract : Martin_2009_Nat.Methods_6_135
ESTHER : Martin_2009_Nat.Methods_6_135
PubMedSearch : Martin_2009_Nat.Methods_6_135
PubMedID: 19137006
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C