hevbr-hnl
Hevea brasiliensis hydroxynitrile lyase (hnl) HbHNL mRNA, complete cds
Comment
Rubber tree hydroxynitrile lyase HbHNL. this enzyme is close to plant esterase SABP2. Few mutations can convert one activity to the other (Padhi et al. Nedrud et al.)
Relationship
Molecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MAFAHFVLIH TICHGAWIWH KLKPLLEALG HKVTALDLAA SGVDPRQIEE IGSFDEYSEP LLTFLEALPP GEKVILVGES CGGLNIAIAA DKYCEKIAAA VFHNSVLPDT EHCPSYVVDK LMEVFPDWKD TTYFTYTKDG KEITGLKLGF TLLRENLYTL CGPEEYELAK MLTRKGSLFQ NILAKRPFFT KEGYGSIKKI YVWTDQDEIF LPEFQLWQIE NYKPDKVYKV EGGDHKLQLT KTKEIAEILQ EVADTYN
References
| Title : Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase - Casadevall_2023_bioRxiv__ |
| Author(s) : Casadevall G , Pierce C , Guan B , Iglesias-Fernandez J , Lim HY , Greenberg LR , Walsh ME , Shi K , Gordon W , Aihara H , Evans RL , Kazlauskas R , Osuna S |
| Ref : Biorxiv , : , 2023 |
| Abstract : Casadevall_2023_bioRxiv__ |
| ESTHER : Casadevall_2023_bioRxiv__ |
| PubMedSearch : Casadevall_2023_bioRxiv__ |
| PubMedID: 37662272 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : A De Novo Designed Esterase with p-Nitrophenyl Acetate Hydrolysis Activity - Li_2020_Molecules_25_4658 |
| Author(s) : Li G , Xu L , Zhang H , Liu J , Yan J , Yan Y |
| Ref : Molecules , 25 :4658 , 2020 |
| Abstract : Li_2020_Molecules_25_4658 |
| ESTHER : Li_2020_Molecules_25_4658 |
| PubMedSearch : Li_2020_Molecules_25_4658 |
| PubMedID: 33066055 |
| Gene_locus related to this paper: aspor-cutas , fusso-cutas , hevbr-hnl |
| Title : Identical active sites in hydroxynitrile lyases show opposite enantioselectivity and reveal possible ancestral mechanism - Jones_2017_ACS.Catal_7_4221 |
| Author(s) : Jones BJ , Bata Z , Kazlauskas RJ |
| Ref : ACS Catal , 7 :4221 , 2017 |
| Abstract : Jones_2017_ACS.Catal_7_4221 |
| ESTHER : Jones_2017_ACS.Catal_7_4221 |
| PubMedSearch : Jones_2017_ACS.Catal_7_4221 |
| PubMedID: 28798888 |
| Gene_locus related to this paper: arath-HNL , hevbr-hnl |
| Title : Evolution of a Catalytic Mechanism - Rauwerdink_2016_Mol.Biol.Evol_33_971 |
| Author(s) : Rauwerdink A , Lunzer M , Devamani T , Jones B , Mooney J , Zhang ZJ , Xu JH , Kazlauskas RJ , Dean AM |
| Ref : Molecular Biology Evolution , 33 :971 , 2016 |
| Abstract : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
| ESTHER : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
| PubMedSearch : Rauwerdink_2016_Mol.Biol.Evol_33_971 |
| PubMedID: 26681154 |
| Gene_locus related to this paper: 9zzzz-5TDX , hevbr-hnl |
| Title : Uncovering divergent evolution of alpha\/beta-hydrolases: a surprising residue substitution needed to convert hydroxynitrile lyase into an esterase - Nedrud_2014_Chem.Sci_5_4265 |
| Author(s) : Nedrud DM , Lin H , Lopez G , Padhi SK , Legatt GA , Kazlauskas RJ |
| Ref : Chem Sci , 5 :4265 , 2014 |
| Abstract : Nedrud_2014_Chem.Sci_5_4265 |
| ESTHER : Nedrud_2014_Chem.Sci_5_4265 |
| PubMedSearch : Nedrud_2014_Chem.Sci_5_4265 |
| PubMedID: 25346843 |
| Gene_locus related to this paper: hevbr-hnl , nicta-SABP2 |
| Title : Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions - Padhi_2010_Chem.Biol_17_863 |
| Author(s) : Padhi SK , Fujii R , Legatt GA , Fossum SL , Berchtold R , Kazlauskas RJ |
| Ref : Chemical Biology , 17 :863 , 2010 |
| Abstract : Padhi_2010_Chem.Biol_17_863 |
| ESTHER : Padhi_2010_Chem.Biol_17_863 |
| PubMedSearch : Padhi_2010_Chem.Biol_17_863 |
| PubMedID: 20797615 |
| Gene_locus related to this paper: hevbr-hnl , nicta-SABP2 |
| Title : Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha\/beta-hydrolase fold - Guterl_2009_J.Biotechnol_141_166 |
| Author(s) : Guterl JK , Andexer JN , Sehl T , von Langermann J , Frindi-Wosch I , Rosenkranz T , Fitter J , Gruber K , Kragl U , Eggert T , Pohl M |
| Ref : J Biotechnol , 141 :166 , 2009 |
| Abstract : Guterl_2009_J.Biotechnol_141_166 |
| ESTHER : Guterl_2009_J.Biotechnol_141_166 |
| PubMedSearch : Guterl_2009_J.Biotechnol_141_166 |
| PubMedID: 19433222 |
| Gene_locus related to this paper: arath-HNL , hevbr-hnl , manes-hnl |
| Title : Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis - Schmidt_2008_J.Biol.Chem_283_21827 |
| Author(s) : Schmidt A , Gruber K , Kratky C , Lamzin VS |
| Ref : Journal of Biological Chemistry , 283 :21827 , 2008 |
| Abstract : Schmidt_2008_J.Biol.Chem_283_21827 |
| ESTHER : Schmidt_2008_J.Biol.Chem_283_21827 |
| PubMedSearch : Schmidt_2008_J.Biol.Chem_283_21827 |
| PubMedID: 18524775 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis - Gartler_2007_J.Biotechnol_129_87 |
| Author(s) : Gartler G , Kratky C , Gruber K |
| Ref : J Biotechnol , 129 :87 , 2007 |
| Abstract : Gartler_2007_J.Biotechnol_129_87 |
| ESTHER : Gartler_2007_J.Biotechnol_129_87 |
| PubMedSearch : Gartler_2007_J.Biotechnol_129_87 |
| PubMedID: 17250917 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Reaction mechanism of hydroxynitrile lyases of the alpha\/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236 - Gruber_2004_J.Biol.Chem_279_20501 |
| Author(s) : Gruber K , Gartler G , Krammer B , Schwab H , Kratky C |
| Ref : Journal of Biological Chemistry , 279 :20501 , 2004 |
| Abstract : Gruber_2004_J.Biol.Chem_279_20501 |
| ESTHER : Gruber_2004_J.Biol.Chem_279_20501 |
| PubMedSearch : Gruber_2004_J.Biol.Chem_279_20501 |
| PubMedID: 14998991 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis - Zuegg_1999_Protein.Sci_8_1990 |
| Author(s) : Zuegg J , Gruber K , Gugganig M , Wagner UG , Kratky C |
| Ref : Protein Science , 8 :1990 , 1999 |
| Abstract : Zuegg_1999_Protein.Sci_8_1990 |
| ESTHER : Zuegg_1999_Protein.Sci_8_1990 |
| PubMedSearch : Zuegg_1999_Protein.Sci_8_1990 |
| PubMedID: 10548044 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Hydroxynitrile lyase from Hevea brasiliensis: molecular characterization and mechanism of enzyme catalysis - Hasslacher_1997_Proteins_27_438 |
| Author(s) : Hasslacher M , Kratky C , Griengl H , Schwab H , Kohlwein SD |
| Ref : Proteins , 27 :438 , 1997 |
| Abstract : Hasslacher_1997_Proteins_27_438 |
| ESTHER : Hasslacher_1997_Proteins_27_438 |
| PubMedSearch : Hasslacher_1997_Proteins_27_438 |
| PubMedID: 9094745 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Molecular cloning of the full-length cDNA of (S)-hydroxynitrile lyase from Hevea brasiliensis. Functional expression in Escherichia coli and Saccharomyces cerevisiae and identification of an active site residue - Hasslacher_1996_J.Biol.Chem_271_5884 |
| Author(s) : Hasslacher M , Schall M , Hayn M , Griengl H , Kohlwein SD , Schwab H |
| Ref : Journal of Biological Chemistry , 271 :5884 , 1996 |
| Abstract : Hasslacher_1996_J.Biol.Chem_271_5884 |
| ESTHER : Hasslacher_1996_J.Biol.Chem_271_5884 |
| PubMedSearch : Hasslacher_1996_J.Biol.Chem_271_5884 |
| PubMedID: 8621461 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : (S)-hydroxynitrile lyase from Hevea brasiliensis - |
| Author(s) : Hasslacher M , Schall M , Hayn M , Griengl H , Kohlwein SD , Schwab H |
| Ref : Annals of the New York Academy of Sciences , 799 :707 , 1996 |
| PubMedID: 8958122 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Mechanism of cyanogenesis: the crystal structure of hydroxynitrile lyase from Hevea brasiliensis - Wagner_1996_Structure_4_811 |
| Author(s) : Wagner UG , Hasslacher M , Griengl H , Schwab H , Kratky C |
| Ref : Structure , 4 :811 , 1996 |
| Abstract : Wagner_1996_Structure_4_811 |
| ESTHER : Wagner_1996_Structure_4_811 |
| PubMedSearch : Wagner_1996_Structure_4_811 |
| PubMedID: 8805565 |
| Gene_locus related to this paper: hevbr-hnl |