9noca-q5j1q6
Nocardia uniformis subsp. tsuyamanensis nocB TE domain nonribosomal peptide synthetase thioesterase module
Comment
Here only C-term Thioesterase module 1708-1921\/1925 aa. The NRPS (nonribosomal peptide synthetase) enzyme that produce the -lactam antibiotic nocardicin A. Nocardicin G, the simplest of the nocardicins and the precursor of nocardicin A. The nocardicin A core is ultimately derived from three amino acids, two nonproteinogenic D-(p-hydroxyphenyl)glycine (D-Hpg) residues surrounding a seryl residue-derived lactam ring. The terminal thioesterase domain (NocTE) exhibited unprecedented epimerase activity to produce the C-terminal D-Hpg
Relationship
Family : Thioesterase
Block : X
Position in NCBI Life Tree : Nocardia uniformis subsp. tsuyamanensis
Molecular evidence
Sequence
Peptide
VEGSGSAYVH TLNPEATGGA LVLVHPGEGL ALPYHGLAPL LPDVRLHVLS DPRFGQSDNR FATLAEMATR YVEWVRTTEP EGPYRLGGWS FGGVVALEMA SQMTAHGDEV SDLLLVDSHN LNAAPRTGDP REGVRQRLVE LGVDPDSPEG VDVVEELLHN GALAAQYAPP AYRGRVSLLV TPTDGDRDAV RARGWDRALL PDLVVEPVPG AHERLFDEEH LSDTADAIRR ALGGER
References
| Title : Late-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases - d'Andrea_2019_Cell.Chem.Biol_26_878 |
| Author(s) : d'Andrea FB , Townsend CA |
| Ref : Cell Chemical Biology , 26 :878 , 2019 |
| Abstract : d'Andrea_2019_Cell.Chem.Biol_26_878 |
| ESTHER : d'Andrea_2019_Cell.Chem.Biol_26_878 |
| PubMedSearch : d'Andrea_2019_Cell.Chem.Biol_26_878 |
| PubMedID: 30982751 |
| Gene_locus related to this paper: 9noca-q5j1q6 |
| Title : Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions - Patel_2019_Nat.Commun_10_3868 |
| Author(s) : Patel KD , d'Andrea FB , Gaudelli NM , Buller AR , Townsend CA , Gulick AM |
| Ref : Nat Commun , 10 :3868 , 2019 |
| Abstract : Patel_2019_Nat.Commun_10_3868 |
| ESTHER : Patel_2019_Nat.Commun_10_3868 |
| PubMedSearch : Patel_2019_Nat.Commun_10_3868 |
| PubMedID: 31455765 |
| Gene_locus related to this paper: 9noca-q5j1q6 |
| Title : Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis - Gaudelli_2014_Nat.Chem.Biol_10_251 |
| Author(s) : Gaudelli NM , Townsend CA |
| Ref : Nat Chemical Biology , 10 :251 , 2014 |
| Abstract : Gaudelli_2014_Nat.Chem.Biol_10_251 |
| ESTHER : Gaudelli_2014_Nat.Chem.Biol_10_251 |
| PubMedSearch : Gaudelli_2014_Nat.Chem.Biol_10_251 |
| PubMedID: 24531841 |
| Gene_locus related to this paper: 9noca-q5j1q6 |
| Title : The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A - Gunsior_2004_Chem.Biol_11_927 |
| Author(s) : Gunsior M , Breazeale SD , Lind AJ , Ravel J , Janc JW , Townsend CA |
| Ref : Chemical Biology , 11 :927 , 2004 |
| Abstract : Gunsior_2004_Chem.Biol_11_927 |
| ESTHER : Gunsior_2004_Chem.Biol_11_927 |
| PubMedSearch : Gunsior_2004_Chem.Biol_11_927 |
| PubMedID: 15271351 |
| Gene_locus related to this paper: 9noca-q5j1q6 |