9actn-l7pij2
Streptomyces flocculus Streptonigrin methylesterase A (StnA) hydrolase
Comment
Streptonigrin (STN) is a highly functionalized aminoquinone antitumor antibiotic produced by Streptomyces flocculus. Streptonigrin methylesterase A (StnA) is one of the tailoring enzymes that modify the aminoquinone skeleton in the biosynthesis pathway of Streptomyces species
Relationship
Molecular evidence
Sequence
Peptide
MTALSRLGEP PSGHDGNSEV RRIAMKRATV PVLRRVAAVC AAALLVTVGT GGPASATGTR SAICRATTVE VTLGKGTGKM WGELCRPAGS SPDTVVTMVH GATYNHNYWD FPYQPDKYSF RKMLNGAGYA TFVVDRLGTG NSTVPPSSEL NLTVEARQMH EVVQGLRTGR IGGTGFGKVV LAGYSLGSAV TSIEASTFHD VDAVLITALG HYNNPAGTQA IIDNGLSPND DPVLKDRHHY DDGYATTKPG SRKHVFYADR PMDPGVLATD ELTKDANVFT EAADPLVIDP AVSRAIDVPV MFALGDRDPL MCGDGYEDCS SQAALRAQEA PFWTSAPSFD VILVEDAGHG LNLVPNTRVY QDASRDWLDR VVGHG
References
| Title : A novel streptonigrin type alkaloid from the Streptomyces flocculus CGMCC 4.1223 mutant stnA\/Q2 - Wang_2020_Nat.Prod.Res__3 |
| Author(s) : Wang X , Xu F , Huang T , Deng Z , Lin S |
| Ref : Nat Prod Res , :1 , 2020 |
| Abstract : Wang_2020_Nat.Prod.Res__3 |
| ESTHER : Wang_2020_Nat.Prod.Res__3 |
| PubMedSearch : Wang_2020_Nat.Prod.Res__3 |
| PubMedID: 33280413 |
| Gene_locus related to this paper: 9actn-l7pij2 |
| Title : Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode - Qian_2017_Sci.Rep_7_40254 |
| Author(s) : Qian T , Wo J , Zhang Y , Song Q , Feng G , Luo R , Lin S , Wu G , Chen HF |
| Ref : Sci Rep , 7 :40254 , 2017 |
| Abstract : Qian_2017_Sci.Rep_7_40254 |
| ESTHER : Qian_2017_Sci.Rep_7_40254 |
| PubMedSearch : Qian_2017_Sci.Rep_7_40254 |
| PubMedID: 28074848 |
| Gene_locus related to this paper: 9actn-l7pij2 |
| Title : Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond - Xu_2013_J.Am.Chem.Soc_135_1739 |
| Author(s) : Xu F , Kong D , He X , Zhang Z , Han M , Xie X , Wang P , Cheng H , Tao M , Zhang L , Deng Z , Lin S |
| Ref : Journal of the American Chemical Society , 135 :1739 , 2013 |
| Abstract : Xu_2013_J.Am.Chem.Soc_135_1739 |
| ESTHER : Xu_2013_J.Am.Chem.Soc_135_1739 |
| PubMedSearch : Xu_2013_J.Am.Chem.Soc_135_1739 |
| PubMedID: 23301954 |
| Gene_locus related to this paper: 9actn-l7pij2 |