human-FAP
Homo sapiens (Human) fibroblast activation protein alpha FAPalpha, integral membrane serine protease seprase FAPA, FAP, SEPR
Comment
Fibroblast activation protein (FAP). However, FAP is not expressed in normal fibroblasts, normal or malignant epithelial cells, or the stroma of benign epithelial tumors. FAP is a cell membrane-bound serine peptidase overexpressed on the surface of cancer-associated fibroblasts. Serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala\/Ser-Gly-Pro-Ser\/Asn\/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. FAP can hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY cleavage product proangiogenic FAP enhances tumor growth progression), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner
Relationship
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
Sequence
Peptide
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP FQITFNGREN KIFNGIPDWV YEEEMLPTKY ALWWSPNGKF LAYAEFNDKD IPVIAYSYYG DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSRPVFSYD AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD
References (12)
| Title : Cell-specific expression of the FAP gene is regulated by enhancer elements - Antonova_2023_Front.Mol.Biosci_10_1111511 |
| Author(s) : Antonova DV , Gnatenko DA , Kotova ES , Pleshkan VV , Kuzmich AI , Didych DA , Sverdlov ED , Alekseenko IV |
| Ref : Front Mol Biosci , 10 :1111511 , 2023 |
| PubMedID: 36825204 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Considerations - Kaneda-Nakashima_2023_PET.Clin_18_397 |
| Author(s) : Kaneda-Nakashima K , Shirakami Y , Kadonaga Y , Watabe T |
| Ref : PET Clin , 18 :397 , 2023 |
| PubMedID: 36997365 |
| Gene_locus related to this paper: human-FAP |
| Title : A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein - Schnapp_2021_ChemMedChem_16_630 |
| Author(s) : Schnapp G , Hoevels Y , Bakker RA , Schreiner P , Klein T , Nar H |
| Ref : ChemMedChem , 16 :630 , 2021 |
| PubMedID: 33030297 |
| Gene_locus related to this paper: human-FAP |
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts - Loktev_2018_J.Nucl.Med_59_1423 |
| Author(s) : Loktev A , Lindner T , Mier W , Debus J , Altmann A , Jager D , Giesel F , Kratochwil C , Barthe P , Roumestand C , Haberkorn U |
| Ref : J Nucl Med , 59 :1423 , 2018 |
| PubMedID: 29626120 |
| Gene_locus related to this paper: human-FAP |
| Title : Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein - Lindner_2018_J.Nucl.Med_59_1415 |
| Author(s) : Lindner T , Loktev A , Altmann A , Giesel F , Kratochwil C , Debus J , Jager D , Mier W , Haberkorn U |
| Ref : J Nucl Med , 59 :1415 , 2018 |
| PubMedID: 29626119 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP) - Bainbridge_2017_Sci.Rep_7_12524 |
| Author(s) : Bainbridge TW , Dunshee DR , Kljavin NM , Skelton NJ , Sonoda J , Ernst JA |
| Ref : Sci Rep , 7 :12524 , 2017 |
| PubMedID: 28970566 |
| Gene_locus related to this paper: human-FAP |
| Title : Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein - Lee_2006_Blood_107_1397 |
| Author(s) : Lee KN , Jackson KW , Christiansen VJ , Lee CS , Chun JG , McKee PA |
| Ref : Blood , 107 :1397 , 2006 |
| PubMedID: 16223769 |
| Gene_locus related to this paper: human-FAP |
| Title : Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha - Aertgeerts_2005_J.Biol.Chem_280_19441 |
| Author(s) : Aertgeerts K , Levin I , Shi L , Snell GP , Jennings A , Prasad GS , Zhang Y , Kraus ML , Salakian S , Sridhar V , Wijnands R , Tennant MG |
| Ref : Journal of Biological Chemistry , 280 :19441 , 2005 |
| PubMedID: 15809306 |
| Gene_locus related to this paper: human-FAP |
| Title : Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform - Goldstein_2000_J.Biol.Chem_275_2554 |
| Author(s) : Goldstein LA , Chen WT |
| Ref : Journal of Biological Chemistry , 275 :2554 , 2000 |
| PubMedID: 10644713 |
| Gene_locus related to this paper: human-FAP |
| Title : Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease - Pineiro-Sanchez_1997_J.Biol.Chem_272_7595 |
| Author(s) : Pineiro-Sanchez ML , Goldstein LA , Dodt J , Howard L , Yeh Y , Tran H , Argraves WS , Chen WT |
| Ref : Journal of Biological Chemistry , 272 :7595 , 1997 |
| PubMedID: 9065413 |
| Gene_locus related to this paper: human-FAP |
| Title : Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers - Scanlan_1994_Proc.Natl.Acad.Sci.U.S.A_91_5657 |
| Author(s) : Scanlan MJ , Raj BK , Calvo B , Garin-Chesa P , Sanz-Moncasi MP , Healey JH , Old LJ , Rettig WJ |
| Ref : Proc Natl Acad Sci U S A , 91 :5657 , 1994 |
| PubMedID: 7911242 |
| Gene_locus related to this paper: human-FAP |