abh_upf0017
Relationship
Comment
This family includes: Escherichia coli yheT (Zhang et al. 1998); Yeast YBR177c (octanoyl-CoA:ethanol acyltransferase thioesterase), YMR210w, YPL095c; Mammalian ABHD1/2/3/15 are included. Human protein ABHD1, ABHD2 (pHPS1-2), ABHD3, ABHD15 (an essential component in the development of adipocytes as well as in apoptosis Walenta et al. 2013)
Human ABHD3 is a phospholipase that may play a role in phospholipids remodeling. It may selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position; Enhanced neointimal hyperplasia was observed in Abhd2-deficient mice, using an experimental vascular cuff placement injury model. Abhd2 is expressed in vascular smooth muscle cells (SMCs). An association between the human ABHD2 gene and colorectal cancer and with Risks for Chronic Obstructive Pulmonary Diseaseis reported. ABHD2 is involved in virus propagation, immune response, and fertilization namely in the P4-stimulated acrosome reaction. Monoacylglycerol lipase ABHD2 is a steroid-activated (progesterone P4) enzyme that hydrolyzes 2-arachidonoylglycerol. ABHD2 is expressed in sperm and in ovaries. ABHD2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle (Bjorkgren et al.) The family also contains: Drosophila protein ABHD2 anon-23D; Picea glauca (white spruce) late embryogenesis abundant protein EMB8 (Dong et al. 1999); and Caenorhabditis elegans C44C1.5. (UPF0017_hydro-like_CS abh_upf0017 IPR000952 (conserved site) is included in IPR012020 Hydrolase_YheT in Interpro. ABHD15 does not have a serine in the position of the catalytic triad. TAMRA-FP probe does not interact with ABHD15. ABHD15 has no hydrolase activity. (These entries where previously included in AlphaBeta_hydrolase family in ESTHER). Main substrates include: ABHD2 triacylglycerols, esters; ABHD3 medium-chain phospholipids, phosphatidylcholines containing C14 acyl chain, oxidatively truncated phospholipids Database
Interpro : IPR000952 Uncharacterised protein family UPF0017, hydrolase-like, conserved site , IPR012020 AB hydrolase 4 family, AB-hydrolase YheT, putative ABHD4 , IPR000952 UPF0017_hydro-like_CS
PIRSF : PIRSF005211 Ab_hydro_YheT
Pdoc : PDOC00872
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (24)
| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_bioRxiv__ |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : Biorxiv , : , 2023 |
| Abstract : Price_2023_bioRxiv__ |
| ESTHER : Price_2023_bioRxiv__ |
| PubMedSearch : Price_2023_bioRxiv__ |
| PubMedID: 36993241 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men - Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| Author(s) : Jiang F , Zhu Y , Chen Y , Tang X , Liu L , Chen G , Liu Y , Sun X |
| Ref : J Internal Medicine Res , 49 :300060521999527 , 2021 |
| Abstract : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| ESTHER : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| PubMedSearch : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| PubMedID: 33752482 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Alpha\/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle - Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| Author(s) : Bjorkgren I , Chung DH , Mendoza S , Gabelev-Khasin L , Modzelewski A , He L , Lishko PV |
| Ref : Front Cell Developmental Biology , 9 :710864 , 2021 |
| Abstract : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| ESTHER : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| PubMedSearch : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| PubMedID: 34568325 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT\/p70S6K and JNK Pathways through ABHD2 - He_2020_Mol.Ther.Oncolytics_17_83 |
| Author(s) : He Y , Yang Y , Liao Y , Xu J , Liu L , Li C , Xiong X |
| Ref : Mol Ther Oncolytics , 17 :83 , 2020 |
| Abstract : He_2020_Mol.Ther.Oncolytics_17_83 |
| ESTHER : He_2020_Mol.Ther.Oncolytics_17_83 |
| PubMedSearch : He_2020_Mol.Ther.Oncolytics_17_83 |
| PubMedID: 32322665 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : A large-scale genome-lipid association map guides lipid identification - Linke_2020_Nat.Metab_2_1149 |
| Author(s) : Linke V , Overmyer KA , Miller IJ , Brademan DR , Hutchins PD , Trujillo EA , Reddy TR , Russell JD , Cushing EM , Schueler KL , Stapleton DS , Rabaglia ME , Keller MP , Gatti DM , Keele GR , Pham D , Broman KW , Churchill GA , Attie AD , Coon JJ |
| Ref : Nat Metab , 2 :1149 , 2020 |
| Abstract : Linke_2020_Nat.Metab_2_1149 |
| ESTHER : Linke_2020_Nat.Metab_2_1149 |
| PubMedSearch : Linke_2020_Nat.Metab_2_1149 |
| PubMedID: 32958938 |
| Gene_locus related to this paper: human-ABHD1 , human-ABHD3 |
| Title : Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2 - Yu_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Yu M , Zhang L , Liu Y , Liu D , Guo Z |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : Yu_2019_Int.J.Mol.Sci_20_ |
| ESTHER : Yu_2019_Int.J.Mol.Sci_20_ |
| PubMedSearch : Yu_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 31035455 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation - Stockli_2019_Mol.Metab_25_83 |
| Author(s) : Stockli J , Zadoorian A , Cooke KC , Deshpande V , Yau B , Herrmann G , Kebede MA , Humphrey SJ , James DE |
| Ref : Mol Metab , 25 :83 , 2019 |
| Abstract : Stockli_2019_Mol.Metab_25_83 |
| ESTHER : Stockli_2019_Mol.Metab_25_83 |
| PubMedSearch : Stockli_2019_Mol.Metab_25_83 |
| PubMedID: 31105056 |
| Gene_locus related to this paper: human-ABHD15 , mouse-ABH15 |
| Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M |
| Ref : ACS Chemical Biology , 14 :2295 , 2019 |
| Abstract : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| ESTHER : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedID: 31525885 |
| Gene_locus related to this paper: human-ABHD2 , human-ABHD3 |
| Title : Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance - Xia_2018_Cell.Rep_23_1948 |
| Author(s) : Xia W , Pessentheiner AR , Hofer DC , Amor M , Schreiber R , Schoiswohl G , Eichmann TO , Walenta E , Itariu B , Prager G , Hackl H , Stulnig T , Kratky D , Rulicke T , Bogner-Strauss JG |
| Ref : Cell Rep , 23 :1948 , 2018 |
| Abstract : Xia_2018_Cell.Rep_23_1948 |
| ESTHER : Xia_2018_Cell.Rep_23_1948 |
| PubMedSearch : Xia_2018_Cell.Rep_23_1948 |
| PubMedID: 29768196 |
| Gene_locus related to this paper: human-ABHD15 , mouse-ABH15 |
| Title : Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids - Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| Author(s) : Mannowetz N , Miller MR , Lishko PV |
| Ref : Proc Natl Acad Sci U S A , 114 :5743 , 2017 |
| Abstract : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| ESTHER : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| PubMedSearch : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| PubMedID: 28507119 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC |
| Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017 |
| Abstract : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| ESTHER : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedSearch : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedID: 28684316 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes - Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| Author(s) : Rondini EA , Mladenovic-Lucas L , Roush WR , Halvorsen GT , Green AE , Granneman JG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :367 , 2017 |
| Abstract : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| ESTHER : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedSearch : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedID: 28928121 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |
| Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone - Miller_2016_Science_352_555 |
| Author(s) : Miller MR , Mannowetz N , Iavarone AT , Safavi R , Gracheva EO , Smith JF , Hill RZ , Bautista DM , Kirichok Y , Lishko PV |
| Ref : Science , 352 :555 , 2016 |
| Abstract : Miller_2016_Science_352_555 |
| ESTHER : Miller_2016_Science_352_555 |
| PubMedSearch : Miller_2016_Science_352_555 |
| PubMedID: 26989199 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Associations of ABHD2 Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population - Liu_2015_PLoS.One_10_e0123929 |
| Author(s) : Liu L , Li X , Yuan R , Zhang H , Qiang L , Shen J , Jin S |
| Ref : PLoS ONE , 10 :e0123929 , 2015 |
| Abstract : Liu_2015_PLoS.One_10_e0123929 |
| ESTHER : Liu_2015_PLoS.One_10_e0123929 |
| PubMedSearch : Liu_2015_PLoS.One_10_e0123929 |
| PubMedID: 25880496 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : The yeast enzyme Eht1 is an octanoyl-CoA:ethanol acyltransferase that also functions as a thioesterase - Knight_2014_Yeast_31_463 |
| Author(s) : Knight MJ , Bull ID , Curnow P |
| Ref : Yeast , 31 :463 , 2014 |
| Abstract : Knight_2014_Yeast_31_463 |
| ESTHER : Knight_2014_Yeast_31_463 |
| PubMedSearch : Knight_2014_Yeast_31_463 |
| PubMedID: 25308280 |
| Gene_locus related to this paper: yeast-MCFS2 |
| Title : alpha\/beta-Hydrolase Domain Containing Protein 15 (ABHD15) - an Adipogenic Protein Protecting from Apoptosis - Walenta_2013_PLoS.One_8_e79134 |
| Author(s) : Walenta E , Pessentheiner AR , Pelzmann HJ , Deutsch A , Goeritzer M , Kratky D , Hackl H , Oh da Y , Prokesch A , Bogner-Strauss JG |
| Ref : PLoS ONE , 8 :e79134 , 2013 |
| Abstract : Walenta_2013_PLoS.One_8_e79134 |
| ESTHER : Walenta_2013_PLoS.One_8_e79134 |
| PubMedSearch : Walenta_2013_PLoS.One_8_e79134 |
| PubMedID: 24236098 |
| Gene_locus related to this paper: human-ABHD15 |
| Title : Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids - Long_2011_Nat.Chem.Biol_7_763 |
| Author(s) : Long JZ , Cisar JS , Milliken D , Niessen S , Wang C , Trauger SA , Siuzdak G , Cravatt BF |
| Ref : Nat Chemical Biology , 7 :763 , 2011 |
| Abstract : Long_2011_Nat.Chem.Biol_7_763 |
| ESTHER : Long_2011_Nat.Chem.Biol_7_763 |
| PubMedSearch : Long_2011_Nat.Chem.Biol_7_763 |
| PubMedID: 21926997 |
| Gene_locus related to this paper: human-ABHD3 , mouse-abhd3 |
| Title : Age-related pulmonary emphysema in mice lacking alpha\/beta hydrolase domain containing 2 gene - Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| Author(s) : Jin S , Zhao G , Li Z , Nishimoto Y , Isohama Y , Shen J , Ito T , Takeya M , Araki K , He P , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 380 :419 , 2009 |
| Abstract : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| ESTHER : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| PubMedSearch : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| PubMedID: 19250629 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque - Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| Author(s) : Miyata K , Nakayama M , Mizuta S , Hokimoto S , Sugamura K , Oshima S , Oike Y , Sugiyama S , Ogawa H , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 365 :207 , 2008 |
| Abstract : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| ESTHER : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| PubMedSearch : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| PubMedID: 17980156 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity - Saerens_2006_J.Biol.Chem_281_4446 |
| Author(s) : Saerens SM , Verstrepen KJ , Van Laere SD , Voet AR , Van Dijck P , Delvaux FR , Thevelein JM |
| Ref : Journal of Biological Chemistry , 281 :4446 , 2006 |
| Abstract : Saerens_2006_J.Biol.Chem_281_4446 |
| ESTHER : Saerens_2006_J.Biol.Chem_281_4446 |
| PubMedSearch : Saerens_2006_J.Biol.Chem_281_4446 |
| PubMedID: 16361250 |
| Gene_locus related to this paper: yeast-MCFS1 , yeast-MCFS2 , yeast-ym60 |
| Title : Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha\/beta hydrolase domain containing 2 gene - Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| Author(s) : Miyata K , Oike Y , Hoshii T , Maekawa H , Ogawa H , Suda T , Araki K , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 329 :296 , 2005 |
| Abstract : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| ESTHER : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| PubMedSearch : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| PubMedID: 15721306 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Alpha\/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity - Wisotzkey_2003_J.Mol.Evol_56_351 |
| Author(s) : Wisotzkey RG , Johnson AN , Takaesu NT , Newfeld SJ |
| Ref : Journal of Molecular Evolution , 56 :351 , 2003 |
| Abstract : Wisotzkey_2003_J.Mol.Evol_56_351 |
| ESTHER : Wisotzkey_2003_J.Mol.Evol_56_351 |
| PubMedSearch : Wisotzkey_2003_J.Mol.Evol_56_351 |
| PubMedID: 12612838 |
| Gene_locus related to this paper: drome-abhd2 |
| Title : Cloning and characterization of six embryogenesis-associated cDNAs from somatic embryos of Picea glauca and their comparative expression during zygotic embryogenesis - Dong_1999_Plant.Mol.Biol_39_859 |
| Author(s) : Dong JZ , Dunstan DI |
| Ref : Plant Mol Biol , 39 :859 , 1999 |
| Abstract : Dong_1999_Plant.Mol.Biol_39_859 |
| ESTHER : Dong_1999_Plant.Mol.Biol_39_859 |
| PubMedSearch : Dong_1999_Plant.Mol.Biol_39_859 |
| PubMedID: 10350098 |
| Gene_locus related to this paper: picgl-emb8 |
| Title : Functional analysis of the Escherichia coli genome for members of the alpha\/beta hydrolase family - Zhang_1998_Fold.Des_3_535 |
| Author(s) : Zhang L , Godzik A , Skolnick J , Fetrow JS |
| Ref : Fold Des , 3 :535 , 1998 |
| Abstract : Zhang_1998_Fold.Des_3_535 |
| ESTHER : Zhang_1998_Fold.Des_3_535 |
| PubMedSearch : Zhang_1998_Fold.Des_3_535 |
| PubMedID: 9889164 |
No structure scheme yet for this family
Genes Proteins in abh_upf0017 family (730)
Fragments of genes in abh_upf0017 family (50)
No fragment of genesSubstrates in abh_upf0017 family (9)
Inhibitors in abh_upf0017 family (5)