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S9N_PPCE_Peptidase_S9

Relationship

Family: S9N_PPCE_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme PPCE, Prolyl endopeptidase PE, prolyl oligopeptidase POP). Prolyl oligopeptidases are either located in the cytosol or they are membrane bound, where they cleave peptide bonds with prolyl P1 specificities (but cleavage of alanyl bonds has been detected). The proline must adopt a trans con- figuration within the chain. Peptides of up to 30 residues are cleaved. N-terminal domain is a 7-bladed beta-propeller

Database

Interpro : IPR004106 Peptidase S9A\/B\/C, oligopeptidase, N-terminal beta-propeller , IPR001375 Peptidase_S9

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9 , PF02897 Peptidase_S9_N

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (6)

Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387
Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I
Ref : Front Immunol , 6 :387 , 2015
Abstract : Waumans_2015_Front.Immunol_6_387
ESTHER : Waumans_2015_Front.Immunol_6_387
PubMedSearch : Waumans_2015_Front.Immunol_6_387
PubMedID: 26300881

Title : Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity - Di Daniel_2009_Mol.Cell.Neurosci_41_373
Author(s) : Di Daniel E , Glover CP , Grot E , Chan MK , Sanderson TH , White JH , Ellis CL , Gallagher KT , Uney J , Thomas J , Maycox PR , Mudge AW
Ref : Molecular & Cellular Neurosciences , 41 :373 , 2009
Abstract : Di Daniel_2009_Mol.Cell.Neurosci_41_373
ESTHER : Di Daniel_2009_Mol.Cell.Neurosci_41_373
PubMedSearch : Di Daniel_2009_Mol.Cell.Neurosci_41_373
PubMedID: 19332125
Gene_locus related to this paper: mouse-ppce

Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349
Author(s) : Polgar L
Ref : Cell Mol Life Sciences , 59 :349 , 2002
Abstract : Polgar_2002_Cell.Mol.Life.Sci_59_349
ESTHER : Polgar_2002_Cell.Mol.Life.Sci_59_349
PubMedSearch : Polgar_2002_Cell.Mol.Life.Sci_59_349
PubMedID: 11915948

Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277
Author(s) : Fulop V , Szeltner Z , Polgar L
Ref : EMBO Rep , 1 :277 , 2000
Abstract : Fulop_2000_EMBO.Rep_1_277
ESTHER : Fulop_2000_EMBO.Rep_1_277
PubMedSearch : Fulop_2000_EMBO.Rep_1_277
PubMedID: 11256612
Gene_locus related to this paper: pig-ppce

Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161
Author(s) : Fulop V , Bocskei Z , Polgar L
Ref : Cell , 94 :161 , 1998
Abstract : Fulop_1998_Cell_94_161
ESTHER : Fulop_1998_Cell_94_161
PubMedSearch : Fulop_1998_Cell_94_161
PubMedID: 9695945
Gene_locus related to this paper: pig-ppce

Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281
Author(s) : Polgar L
Ref : FEBS Letters , 311 :281 , 1992
Abstract : Polgar_1992_FEBS.Lett_311_281
ESTHER : Polgar_1992_FEBS.Lett_311_281
PubMedSearch : Polgar_1992_FEBS.Lett_311_281
PubMedID: 1397329

Structures (66)

Genes Proteins in S9N_PPCE_Peptidase_S9 family (143)

Fragments of genes in S9N_PPCE_Peptidase_S9 family (3)

Structures in S9N_PPCE_Peptidase_S9 family (66)

Substrates in S9N_PPCE_Peptidase_S9 family (10)

Inhibitors in S9N_PPCE_Peptidase_S9 family (30)