PAF-Acetylhydrolase
Relationship
Comment
Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2 (group-VIIA), responsible for inactivation of platelet-activating factor through cleavage of an acetyl group (PAF: Extracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors). Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, (whose subunits are not alpha/beta hydrolases), the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). Both these last two forms are alpha/beta hydrolases and are included in this family. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene (human-PLA2G7).
This family also contains microbial lipase homologue of PAF-AH_p_II. The first sructure known was Streptomyces exfoliatus lipase Database
Interpro : IPR005065 PAF_Ac_hydrop_II , IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF03403 PAF-AH_p_II
Prints : PR00821
EC Number : No EC Number
References (5)
| Title : Lipoprotein-associated phospholipase A2: The story continues - Huang_2020_Med.Res.Rev_40_79 |
| Author(s) : Huang F , Wang K , Shen J |
| Ref : Med Res Rev , 40 :79 , 2020 |
| Abstract : Huang_2020_Med.Res.Rev_40_79 |
| ESTHER : Huang_2020_Med.Res.Rev_40_79 |
| PubMedSearch : Huang_2020_Med.Res.Rev_40_79 |
| PubMedID: 31140638 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening - Woolford_2016_J.Med.Chem_59_5356 |
| Author(s) : Woolford AJ , Pero JE , Aravapalli S , Berdini V , Coyle JE , Day PJ , Dodson AM , Grondin P , Holding FP , Lee LY , Li P , Manas ES , Marino J, Jr. , Martin AC , McCleland BW , McMenamin RL , Murray CW , Neipp CE , Page LW , Patel VK , Potvain F , Rich S , Rivero RA , Smith K , Somers DO , Trottet L , Velagaleti R , Williams G , Xie R |
| Ref : Journal of Medicinal Chemistry , 59 :5356 , 2016 |
| Abstract : Woolford_2016_J.Med.Chem_59_5356 |
| ESTHER : Woolford_2016_J.Med.Chem_59_5356 |
| PubMedSearch : Woolford_2016_J.Med.Chem_59_5356 |
| PubMedID: 27167608 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115 |
| Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 59 :5115 , 2016 |
| Abstract : Liu_2016_J.Med.Chem_59_5115 |
| ESTHER : Liu_2016_J.Med.Chem_59_5115 |
| PubMedSearch : Liu_2016_J.Med.Chem_59_5115 |
| PubMedID: 27078579 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis - Samanta_2008_J.Biol.Chem_283_31617 |
| Author(s) : Samanta U , Bahnson BJ |
| Ref : Journal of Biological Chemistry , 283 :31617 , 2008 |
| Abstract : Samanta_2008_J.Biol.Chem_283_31617 |
| ESTHER : Samanta_2008_J.Biol.Chem_283_31617 |
| PubMedSearch : Samanta_2008_J.Biol.Chem_283_31617 |
| PubMedID: 18784071 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution - Wei_1998_Structure_6_511 |
| Author(s) : Wei Y , Swenson L , Castro C , Derewenda U , Minor W , Arai H , Aoki J , Inoue K , Servin-Gonzalez L , Derewenda ZS |
| Ref : Structure , 6 :511 , 1998 |
| Abstract : Wei_1998_Structure_6_511 |
| ESTHER : Wei_1998_Structure_6_511 |
| PubMedSearch : Wei_1998_Structure_6_511 |
| PubMedID: 9562561 |
| Gene_locus related to this paper: strex-lipas |
Structures (35)
Genes Proteins in PAF-Acetylhydrolase family (145)
Fragments of genes in PAF-Acetylhydrolase family (3)
Structures in PAF-Acetylhydrolase family (35)Substrates in PAF-Acetylhydrolase family (6)
Inhibitors in PAF-Acetylhydrolase family (35)